PMID- 24906975
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 37
IP  - 8
DP  - 2014 Aug
TI  - Relationship between glucose metabolism and non-alcoholic fatty liver disease 
      severity in morbidly obese women.
PG  - 739-744
LID - 10.1007/s40618-014-0101-x [doi]
AB  - BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an independent predictor 
      of type 2 diabetes mellitus (T2DM). Insulin resistance and beta-cell dysfunction 
      are involved in the pathogenesis of T2DM. Insulin resistance is associated with 
      NAFLD but little is known about beta-cell dysfunction and NAFLD. AIM: We tested 
      whether NAFLD severity is associated with insulin sensitivity and beta-cell 
      function in morbidly obese women. SUBJECTS AND METHODS: We studied 61 Caucasian 
      women aged 18-60 years without T2DM and with a body mass index ranging from 35.3 
      to 48.8 kg/m(2). The insulin sensitivity index (ISI) and the disposition index (DI) 
      from oral glucose tolerance testing were used as measures of insulin sensitivity 
      and beta-cell function, respectively. Fat was measured by dual-energy X-ray 
      absorptiometry. Fatty liver was diagnosed by ultrasonography and ordinally coded 
      as 0 = none, 1 = light, 2 = moderate, 3 = severe. Proportional-odds logistic 
      regression was used to evaluate the association of NAFLD severity with log(e)ISI 
      and log(e)DI with and without correction for total and truncal fat. RESULTS: The 
      odds of more severe vs. less severe NAFLD decreased for increasing log(e)ISI 
      [odds ratio (OR) 0.40, 95 % CI 0.19-0.84, p < 0.05] and log(e)DI (OR 0.80, 95 % 
      CI 0.69-0.92, p < 0.01). Neither total nor truncal fat had any effect on these 
      associations. CONCLUSION: In morbidly obese women, NAFLD severity is inversely 
      associated with insulin sensitivity and beta-cell function. The association of 
      NAFLD severity with beta-cell dysfunction is stronger than that with insulin 
      resistance.
FAU - Bedogni, Giorgio
AU  - Bedogni G
AD  - Liver Research Center, AREA Science Park, Building Q, Strada Statale 14 km 163.5, 
      Basovizza, 34012, Trieste, Italy. giorgiobedogni@gmail.com.
AD  - International Center for the Assessment of Nutritional Status (ICANS), University 
      of Milano, Milan, Italy. giorgiobedogni@gmail.com.
FAU - Gastaldelli, Amalia
AU  - Gastaldelli A
AD  - Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche (CNR), Pisa, 
      Italy.
FAU - Tiribelli, Claudio
AU  - Tiribelli C
AD  - Liver Research Center, AREA Science Park, Building Q, Strada Statale 14 km 163.5, 
      Basovizza, 34012, Trieste, Italy.
FAU - Agosti, Fiorenza
AU  - Agosti F
AD  - Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for 
      Auxo-Endocrinological Research, Milano, Italy.
FAU - De Col, Alessandra
AU  - De Col A
AD  - Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for 
      Auxo-Endocrinological Research, Milano, Italy.
FAU - Fessehatsion, Rezene
AU  - Fessehatsion R
AD  - Istituto Auxologico Italiano, IRCCS, Division of Metabolic Diseases, Verbania, 
      Italy.
FAU - Sartorio, Alessandro
AU  - Sartorio A
AD  - Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for 
      Auxo-Endocrinological Research, Milano, Italy.
AD  - Istituto Auxologico Italiano, IRCCS, Division of Metabolic Diseases, Verbania, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140607
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Insulin)
SB  - IM
MH  - Abdominal Fat/diagnostic imaging
MH  - Absorptiometry, Photon
MH  - Adiposity
MH  - Adolescent
MH  - Adult
MH  - Body Mass Index
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/*metabolism
MH  - *Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/*metabolism
MH  - Italy
MH  - Liver/diagnostic imaging
MH  - Logistic Models
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/diagnostic 
      imaging/etiology/*metabolism/physiopathology
MH  - Obesity, Morbid/*physiopathology
MH  - Severity of Illness Index
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2014/06/08 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/06/08 06:00
PHST- 2014/03/28 00:00 [received]
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/06/08 06:00 [entrez]
PHST- 2014/06/08 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1007/s40618-014-0101-x [pii]
AID - 10.1007/s40618-014-0101-x [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2014 Aug;37(8):739-744. doi: 10.1007/s40618-014-0101-x. Epub 
      2014 Jun 7.