PMID- 24907152 OWN - NLM STAT- MEDLINE DCOM- 20150106 LR - 20161125 IS - 1462-0332 (Electronic) IS - 1462-0324 (Linking) VI - 53 IP - 11 DP - 2014 Nov TI - A longitudinal study of ankle brachial pressure indices in a cohort of patients with systemic sclerosis. PG - 2009-13 LID - 10.1093/rheumatology/keu227 [doi] AB - OBJECTIVES: Digital ischaemia, often progressing beyond RP to digital ulceration and sometimes even gangrene, is the most common vascular manifestation of SSc. Both microvascular and macrovascular disease can contribute and coexistence of microvascular and macrovascular (proximal vessel) disease in patients with SSc is potentially limb threatening. The aims of this study were to examine the change over time in the ankle brachial pressure index (ABPI) in a cohort of patients with SSc and to examine whether age, gender, smoking status, disease duration, disease subtype and ACA are associated with ABPI. METHODS: The clinical and laboratory data of 217 patients attending the SSc clinic at a tertiary referral centre and who had their ABPIs checked between 1996 and 2011 were reviewed retrospectively. Data were analysed to see how the ABPI changed with time and linear mixed effects modelling was used to determine which factors were associated with ABPI. RESULTS: In most patients with SSc, the ABPI remained constant over time [median rate of change 0 units/year, interquartile range (IQR) -0.01-0.01]. There was a significant association between lower ABPI and increasing age (P = 0.04), the limited cutaneous subtype of SSc (P = 0.01) and ACA positivity (P = 0.03). Additionally there was an association between ABPI and smoking status of borderline statistical significance (P = 0.08). CONCLUSION: This study provides further evidence for associations between the severity of vascular disease in patients with SSc and increasing age, smoking, limited cutaneous disease and positive ACA. Reassuringly, in most patients ABPI remains stable over time. CI - (c) The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Wig, Surabhi AU - Wig S AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. FAU - Wilkinson, Jack AU - Wilkinson J AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. FAU - Moore, Tonia AU - Moore T AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. FAU - Manning, Joanne AU - Manning J AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. FAU - Chevance, Aurelie AU - Chevance A AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. FAU - Vail, Andy AU - Vail A AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. FAU - Herrick, Ariane L AU - Herrick AL AD - Centre for Musculoskeletal Research, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, Rheumatology Directorate, Salford Royal NHS Foundation Trust, Salford, UK and Institute of Public Health Epidemiology and Development, University of Bordeaux Segalen, Bordeaux, France. ariane.herrick@manchester.ac.uk. LA - eng PT - Journal Article DEP - 20140606 PL - England TA - Rheumatology (Oxford) JT - Rheumatology (Oxford, England) JID - 100883501 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Ankle/*blood supply MH - Ankle Brachial Index/*methods MH - Blood Pressure/*physiology MH - Brachial Artery/*diagnostic imaging/physiopathology MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Peripheral Vascular Diseases/diagnosis/etiology/*physiopathology MH - Prognosis MH - Retrospective Studies MH - Scleroderma, Systemic/complications/diagnosis/*physiopathology MH - Severity of Illness Index MH - Ultrasonography, Doppler/*methods MH - Young Adult OTO - NOTNLM OT - ankle brachial pressure index OT - arterial Doppler OT - peripheral vascular disease OT - systemic sclerosis EDAT- 2014/06/08 06:00 MHDA- 2015/01/07 06:00 CRDT- 2014/06/08 06:00 PHST- 2014/06/08 06:00 [entrez] PHST- 2014/06/08 06:00 [pubmed] PHST- 2015/01/07 06:00 [medline] AID - keu227 [pii] AID - 10.1093/rheumatology/keu227 [doi] PST - ppublish SO - Rheumatology (Oxford). 2014 Nov;53(11):2009-13. doi: 10.1093/rheumatology/keu227. Epub 2014 Jun 6.