PMID- 24907297
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140609
LR  - 20220318
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 2
IP  - 6
DP  - 2014 Jun 1
TI  - Effects of systemic hypoxia on human muscular adaptations to resistance exercise 
      training.
LID - 10.14814/phy2.12033 [doi]
LID - e12033
AB  - Hypoxia is an important modulator of endurance exercise-induced oxidative 
      adaptations in skeletal muscle. However, whether hypoxia affects resistance 
      exercise-induced muscle adaptations remains unknown. Here, we determined the 
      effect of resistance exercise training under systemic hypoxia on muscular 
      adaptations known to occur following both resistance and endurance exercise 
      training, including muscle cross-sectional area (CSA), one-repetition maximum 
      (1RM), muscular endurance, and makers of mitochondrial biogenesis and 
      angiogenesis, such as peroxisome proliferator-activated receptor-gamma coactivator-1alpha 
      (PGC-1alpha), citrate synthase (CS) activity, nitric oxide synthase (NOS), vascular 
      endothelial growth factor (VEGF), hypoxia-inducible factor-1 (HIF-1), and 
      capillary-to-fiber ratio. Sixteen healthy male subjects were randomly assigned to 
      either a normoxic resistance training group (NRT, n = 7) or a hypoxic (14.4% 
      oxygen) resistance training group (HRT, n = 9) and performed 8 weeks of 
      resistance training. Blood and muscle biopsy samples were obtained before and 
      after training. After training muscle CSA of the femoral region, 1RM for 
      bench-press and leg-press, muscular endurance, and skeletal muscle VEGF protein 
      levels significantly increased in both groups. The increase in muscular endurance 
      was significantly higher in the HRT group. Plasma VEGF concentration and skeletal 
      muscle capillary-to-fiber ratio were significantly higher in the HRT group than 
      the NRT group following training. Our results suggest that, in addition to 
      increases in muscle size and strength, HRT may also lead to increased muscular 
      endurance and the promotion of angiogenesis in skeletal muscle.
CI  - (c) 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of the American Physiological Society and The Physiological Society.
FAU - Kon, Michihiro
AU  - Kon M
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan Centre for Physical Activity and Nutrition Research, 
      School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, 
      Australia.
FAU - Ohiwa, Nao
AU  - Ohiwa N
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan.
FAU - Honda, Akiko
AU  - Honda A
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan.
FAU - Matsubayashi, Takeo
AU  - Matsubayashi T
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan.
FAU - Ikeda, Tatsuaki
AU  - Ikeda T
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan.
FAU - Akimoto, Takayuki
AU  - Akimoto T
AD  - Division of Regenerative Medical Engineering, Center for Disease Biology and 
      Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 
      Hongo, BunkyoTokyo, Japan.
FAU - Suzuki, Yasuhiro
AU  - Suzuki Y
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan.
FAU - Hirano, Yuichi
AU  - Hirano Y
AD  - Department of Sports Sciences, Japan Institute of Sports Sciences, 3-15-1 
      Nishigaoka, KitaTokyo, Japan.
FAU - Russell, Aaron P
AU  - Russell AP
AD  - Centre for Physical Activity and Nutrition Research, School of Exercise and 
      Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.
LA  - eng
PT  - Journal Article
DEP - 20140606
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
PMC - PMC4208656
OTO - NOTNLM
OT  - Capillarization
OT  - resistance exercise training
OT  - skeletal muscle
OT  - systemic hypoxia
EDAT- 2014/06/08 06:00
MHDA- 2014/06/08 06:01
PMCR- 2014/06/11
CRDT- 2014/06/08 06:00
PHST- 2014/06/08 06:00 [entrez]
PHST- 2014/06/08 06:00 [pubmed]
PHST- 2014/06/08 06:01 [medline]
PHST- 2014/06/11 00:00 [pmc-release]
AID - 2/6/e12033 [pii]
AID - phy212033 [pii]
AID - 10.14814/phy2.12033 [doi]
PST - epublish
SO  - Physiol Rep. 2014 Jun 6;2(6):e12033. doi: 10.14814/phy2.12033. Print 2014 Jun 1.