PMID- 24907687 OWN - NLM STAT- MEDLINE DCOM- 20150105 LR - 20140714 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 576 DP - 2014 Jul 25 TI - Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used. PG - 6-10 LID - S0304-3940(14)00413-3 [pii] LID - 10.1016/j.neulet.2014.05.041 [doi] AB - Brain-derived neurotrophic factor (BDNF) has key roles in neurodevelopment and synaptic plasticity and is implicated in affective disorders such as anxiety and depression. The aim of the present study was to use BDNF heterozygous mutant rats (HET) and wildtype controls (WT) to investigate the effect of BDNF downregulation on affective behaviours. We also assessed the longterm effects of young-adult stress, here simulated by chronic corticosterone (CORT) treatment. This treatment reduced anxiety-like behaviour in BDNF HET rats on the plus-maze but not in the open-field. There were no genotype or CORT effects on immobility time in the forced swim test. These results show differential effects of CORT treatment on anxiety-like behaviour in BDNF HET rats which were dependent on the experimental paradigms used. While these results do not negate the potential of BDNF HET rats in studies on the role of BDNF in affective disorders, caution is needed about experimental details and the choice of paradigms used. CI - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved. FAU - Gururajan, Anand AU - Gururajan A AD - Behavioral Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia. FAU - Hill, Rachel AU - Hill R AD - Behavioral Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia. FAU - van den Buuse, Maarten AU - van den Buuse M AD - Behavioral Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Australia; School of Psychological Science, La Trobe University, Melbourne, Australia. Electronic address: m.vandenbuuse@latrobe.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140604 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - W980KJ009P (Corticosterone) SB - IM MH - Animals MH - Anxiety/chemically induced/metabolism/*psychology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - *Corticosterone MH - Depression/chemically induced/metabolism/*psychology MH - Genotype MH - Heterozygote MH - Male MH - Maze Learning MH - Motor Activity MH - Rats, Sprague-Dawley OTO - NOTNLM OT - Anxiety OT - Brain-derived neurotrophic factor OT - Corticosterone OT - Depression OT - Mutant rat OT - Stress EDAT- 2014/06/08 06:00 MHDA- 2015/01/06 06:00 CRDT- 2014/06/08 06:00 PHST- 2014/04/01 00:00 [received] PHST- 2014/05/16 00:00 [revised] PHST- 2014/05/19 00:00 [accepted] PHST- 2014/06/08 06:00 [entrez] PHST- 2014/06/08 06:00 [pubmed] PHST- 2015/01/06 06:00 [medline] AID - S0304-3940(14)00413-3 [pii] AID - 10.1016/j.neulet.2014.05.041 [doi] PST - ppublish SO - Neurosci Lett. 2014 Jul 25;576:6-10. doi: 10.1016/j.neulet.2014.05.041. Epub 2014 Jun 4.