PMID- 24908088
OWN - NLM
STAT- MEDLINE
DCOM- 20151109
LR  - 20201116
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Linking)
VI  - 63
IP  - 5
DP  - 2014
TI  - Protection of dopamine neurons by vibration training and up-regulation of 
      brain-derived neurotrophic factor in a MPTP mouse model of Parkinson's disease.
PG  - 649-57
AB  - It is unknown whether the longer duration of vibration training (VT) has a 
      beneficial effect on Parkinson's disease (PD). And also, the mechanisms 
      underlying the reported sensorimotor-improvement in PD induced by short-duration 
      of VT has not been determined. Here, we investigated the effects of longer 
      duration (4 weeks) of low amplitude vibration (LAV) training on the numbers of 
      dopaminergic neurons in the substantia nigra by immunostaining and the levels of 
      dopamine (DA) and brain-derived neurotrophic factor (BDNF) in the striatum by 
      HPLC and ELISA in the chronic MPTP lesion mouse. We demonstrated for the first 
      time that the longer duration of VT could significantly increase the numbers of 
      nigrostriatal DA neurons and the contents of striatal DA and BDNF in the MPTP 
      mice. Our findings implied that longer duration of VT could protect dopaminergic 
      neurons from the MPTP-induced damage probably by upregulating BDNF and also 
      provided evidence for the beneficial effect of longer duration of VT on PD at the 
      cellular and molecular level.
FAU - Zhao, L
AU  - Zhao L
AD  - Laboratory of Neuropharmacology and Department of Neurosurgery, South-west 
      Hospital, The Third Military Medical University, Chongqing , China. 
      zmqian1993@gmail.com and Department of Sports Physiology, Beijing Sport 
      University, Beijing, China. zhaolispring@126.com.
FAU - He, L X
AU  - He LX
FAU - Huang, S N
AU  - Huang SN
FAU - Gong, L J
AU  - Gong LJ
FAU - Li, L
AU  - Li L
FAU - Lv, Y Y
AU  - Lv YY
FAU - Qian, Z M
AU  - Qian ZM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140605
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - *1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dopamine/metabolism
MH  - Dopaminergic Neurons/*metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Parkinsonian Disorders/chemically induced/metabolism/physiopathology/*therapy
MH  - Substantia Nigra/*metabolism/physiopathology
MH  - Time Factors
MH  - Up-Regulation
MH  - *Vibration
EDAT- 2014/06/09 06:00
MHDA- 2015/11/10 06:00
CRDT- 2014/06/09 06:00
PHST- 2014/06/09 06:00 [entrez]
PHST- 2014/06/09 06:00 [pubmed]
PHST- 2015/11/10 06:00 [medline]
AID - 932743 [pii]
AID - 10.33549/physiolres.932743 [doi]
PST - ppublish
SO  - Physiol Res. 2014;63(5):649-57. doi: 10.33549/physiolres.932743. Epub 2014 Jun 5.