PMID- 24908112
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20211021
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 394
IP  - 1-2
DP  - 2014 Sep
TI  - Protective effect of p-methoxycinnamic acid, an active phenolic acid against 
      1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming 
      bacterial enzymes and xenobiotic metabolizing enzymes.
PG  - 187-98
LID - 10.1007/s11010-014-2094-3 [doi]
AB  - Objective of the study is to evaluate the modifying potential of 
      p-methoxycinnamic acid (p-MCA), an active rice bran phenolic acid on 
      biotransforming bacterial enzymes and xenobiotic metabolizing enzymes in 
      1,2-dimethylhydrazine-induced rat colon carcinogenesis. 48 male albino wistar 
      rats were divided into six groups. Group1 (control) received modified pellet diet 
      and 0.1 % carboxymethylcellulose; group2 received modified pellet diet along with 
      p-MCA (80 mg/kg b.wt. p.o.) everyday for 16 weeks; groups 3-6 received 
      1,2-dimethylhydrazine (DMH) (20 mg/kg b.wt.) subcutaneous injection once a week 
      for the first 4 weeks, while groups 4-6 received p-MCA at three different doses 
      of 20, 40 and 80 mg/kg b.wt. p.o. everyday for 16 weeks. A significant increase 
      in carcinogen-activating enzymes (cytochrome P450, cytochrome b5, cytochrome 
      P4502E1, NADH-cytochrome-b5-reductase and NADPH-cytochrome-P450 reductase) with 
      concomitant decrease in phaseII enzymes, DT-Diaphorase, glutathione 
      S-transferase, UDP-glucuronyl-transferase and gamma glutamyltransferase were 
      observed in group3 compared to control. DMH treatment significantly increased the 
      activities of feacal and colonic bacterial enzymes (beta-glucosidase, 
      beta-galactosidase, beta-glucuronidase, nitroreductase, sulphatase and mucinase). p-MCA 
      supplementation (40 mg/kg b.wt) to carcinogen exposed rats inhibited these 
      enzymes, which were near those of control rats. The formation of dysplastic 
      aberrant crypt foci in the colon and the histopathological observations of the 
      liver also supports our biochemical findings. p-MCA (40 mg/kg b.wt.) offers 
      remarkable modulating efficacy of biotransforming bacterial and xenobiotic 
      metabolizing enzymes in colon carcinogenesis.
FAU - Gunasekaran, Sivagami
AU  - Gunasekaran S
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalainagar, 608 002, Tamilnadu, India.
FAU - Venkatachalam, Karthikkumar
AU  - Venkatachalam K
FAU - Jeyavel, Kabalimoorthy
AU  - Jeyavel K
FAU - Namasivayam, Nalini
AU  - Namasivayam N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140608
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Cinnamates)
RN  - 6G4ML8401A (4-methoxycinnamic acid)
RN  - IX068S9745 (1,2-Dimethylhydrazine)
SB  - IM
EIN - Mol Cell Biochem. 2021 May;476(5):2251-2252. PMID: 33779859
MH  - *1,2-Dimethylhydrazine
MH  - Animals
MH  - Anticarcinogenic Agents/*pharmacology
MH  - Bacteria/*drug effects/enzymology
MH  - Biotransformation
MH  - Cinnamates/*pharmacology
MH  - Colon/*drug effects/enzymology/microbiology/pathology
MH  - Colonic Neoplasms/*chemically 
      induced/enzymology/microbiology/pathology/*prevention & control
MH  - Cytoprotection
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Feces/microbiology
MH  - Liver/*drug effects/enzymology
MH  - Male
MH  - Rats, Wistar
EDAT- 2014/06/09 06:00
MHDA- 2015/10/27 06:00
CRDT- 2014/06/09 06:00
PHST- 2013/12/23 00:00 [received]
PHST- 2014/05/15 00:00 [accepted]
PHST- 2014/06/09 06:00 [entrez]
PHST- 2014/06/09 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
AID - 10.1007/s11010-014-2094-3 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2014 Sep;394(1-2):187-98. doi: 10.1007/s11010-014-2094-3. Epub 
      2014 Jun 8.