PMID- 24909443
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20140624
IS  - 2174-2030 (Electronic)
IS  - 0870-2551 (Linking)
VI  - 33
IP  - 5
DP  - 2014 May
TI  - Phenotypic expression in hypertrophic cardiomyopathy and late gadolinium 
      enhancement on cardiac magnetic resonance.
PG  - 261-7
LID - S0870-2551(13)00348-X [pii]
LID - 10.1016/j.repc.2013.10.005 [doi]
AB  - INTRODUCTION AND AIM: The prognostic value of late gadolinium enhancement (LGE) 
      for risk stratification of hypertrophic cardiomyopathy (HCM) patients is the 
      subject of disagreement. We set out to examine the association between clinical 
      and morphological variables, risk factors for sudden cardiac death and LGE in HCM 
      patients. METHODS: From a population of 78 patients with HCM, we studied 53 who 
      underwent cardiac magnetic resonance. They were divided into two groups according 
      to the presence or absence of LGE. Ventricular arrhythmias and morbidity and 
      mortality during follow-up were analyzed. RESULTS: Patients with LGE were younger 
      at the time of diagnosis (p=0.046) and more often had a family history of sudden 
      death (p=0.008) and known coronary artery disease (p=0.086). On echocardiography 
      they had greater maximum wall thickness (p=0.007) and left atrial area (p=0.037) 
      and volume (p=0.035), and more often presented a restrictive pattern of diastolic 
      dysfunction (p=0.011) with a higher E/E ratio (p=0.003) and left ventricular 
      systolic dysfunction (p=0.038). Cardiac magnetic resonance supported the 
      association between LGE and previous echocardiographic findings: greater left 
      atrial area (p=0.029) and maximum wall thickness (p<0.001) and lower left 
      ventricular ejection fraction (p=0.056). Patients with LGE more often had an 
      implantable cardioverter-defibrillator (ICD) (p=0.015). At follow-up, no 
      differences were found in the frequency of ventricular arrhythmias, appropriate 
      ICD therapies or mortality. CONCLUSIONS: The presence of LGE emerges as a risk 
      marker, associated with the classical predictors of sudden cardiac death in this 
      population. However, larger studies are required to confirm its independent 
      association with clinical events.
CI  - Copyright (c) 2013 Sociedade Portuguesa de Cardiologia. Published by Elsevier 
      Espana. All rights reserved.
FAU - Caetano, Francisca
AU  - Caetano F
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal. Electronic address: franciscacaetano@sapo.pt.
FAU - Botelho, Ana
AU  - Botelho A
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
FAU - Trigo, Joana
AU  - Trigo J
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
FAU - Silva, Joana
AU  - Silva J
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
FAU - Almeida, Ines
AU  - Almeida I
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
FAU - Venancio, Margarida
AU  - Venancio M
AD  - Servico de Genetica Medica, Hospital Pediatrico, Centro Hospitalar e 
      Universitario de Coimbra, Coimbra, Portugal.
FAU - Pais, Joao
AU  - Pais J
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
FAU - Sanches, Conceicao
AU  - Sanches C
AD  - Servico de Radiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
FAU - Leitao Marques, Antonio
AU  - Leitao Marques A
AD  - Servico de Cardiologia, Hospital Geral, Centro Hospitalar e Universitario de 
      Coimbra, Coimbra, Portugal.
LA  - eng
LA  - por
PT  - Journal Article
DEP - 20140606
PL  - Portugal
TA  - Rev Port Cardiol
JT  - Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de 
      Cardiologia = Portuguese journal of cardiology : an official journal of the 
      Portuguese Society of Cardiology
JID - 8710716
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Rev Port Cardiol. 2014 May;33(5):269-71. PMID: 24909444
MH  - Cardiac Imaging Techniques/*methods
MH  - Cardiomyopathy, Hypertrophic/complications/*diagnosis/*genetics
MH  - *Contrast Media
MH  - Death, Sudden, Cardiac/etiology
MH  - Female
MH  - *Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - *Phenotype
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Miocardiopatia hipertrofica
OT  - Prognosis
OT  - Prognostico
OT  - Realce tardio
OT  - Ressonancia magnetica cardiaca
EDAT- 2014/06/10 06:00
MHDA- 2016/02/05 06:00
CRDT- 2014/06/10 06:00
PHST- 2013/06/09 00:00 [received]
PHST- 2013/10/08 00:00 [revised]
PHST- 2013/10/19 00:00 [accepted]
PHST- 2014/06/10 06:00 [entrez]
PHST- 2014/06/10 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - S0870-2551(13)00348-X [pii]
AID - 10.1016/j.repc.2013.10.005 [doi]
PST - ppublish
SO  - Rev Port Cardiol. 2014 May;33(5):261-7. doi: 10.1016/j.repc.2013.10.005. Epub 
      2014 Jun 6.