PMID- 24909988
OWN - NLM
STAT- MEDLINE
DCOM- 20140904
LR  - 20191112
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 55
IP  - 4
DP  - 2014
TI  - Feasibility of intracoronary frequency domain optical coherence tomography 
      derived fractional flow reserve for the assessment of coronary artery stenosis.
PG  - 307-11
AB  - Frequency domain optical coherence tomography (FD-OCT) provides cross-sectional 
      images of coronary arteries and deployed stents with micron resolution and 
      measures lumen dimensions with excellent reproducibility. FD-OCT combined with a 
      blood flow resistances model can overcome many limitations of conventional 
      measures of stenosis severity based on quantitative coronary angiography (QCA) 
      and intravascular ultrasound (IVUS). The aim of this feasibility study was to 
      investigate the relationship between pressure derived fractional flow reserve 
      (FFR) and FD-OCT derived FFR, a new method for quantitative measure of stenosis 
      severity that estimates the blood flow resistance and microvascular resistance of 
      the vessel segments imaged by FD-OCT. A total of 26 coronary stenoses in 20 
      patients were studied consecutively with QCA, pressure derived FFR, and FD-OCT. 
      There was a moderate but significant correlation between pressure derived FFR and 
      FD-OCT derived FFR (r = 0.69, P < 0.001). Bland-Altman analysis showed that the 
      mean differences between pressure derived FFR and FD-OCT derived FFR were 0.05 +/- 
      0.14 (limits of agreement: -0.09 to 0.19). The root mean square error (RMSE) 
      between FD-OCT derived FFR and pressure derived FFR was found to be +/- 0.087 FFR 
      units. FD-OCT derived FFR has the potential to become a valuable tool for the 
      assessment of coronary artery stenosis.
FAU - Zafar, Haroon
AU  - Zafar H
AD  - Tissue Optics & Microcirculation Imaging Facility, National University of 
      Ireland, Galway.
FAU - Sharif, Faisal
AU  - Sharif F
FAU - Leahy, Martin J
AU  - Leahy MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140606
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
SB  - IM
MH  - Coronary Angiography
MH  - Coronary Circulation/*physiology
MH  - Coronary Stenosis/*diagnosis/physiopathology
MH  - Coronary Vessels/*physiopathology
MH  - Feasibility Studies
MH  - Female
MH  - Fractional Flow Reserve, Myocardial/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
EDAT- 2014/06/10 06:00
MHDA- 2014/09/05 06:00
CRDT- 2014/06/10 06:00
PHST- 2014/06/10 06:00 [entrez]
PHST- 2014/06/10 06:00 [pubmed]
PHST- 2014/09/05 06:00 [medline]
AID - DN/JST.JSTAGE/ihj/13-362 [pii]
AID - 10.1536/ihj.13-362 [doi]
PST - ppublish
SO  - Int Heart J. 2014;55(4):307-11. doi: 10.1536/ihj.13-362. Epub 2014 Jun 6.