PMID- 24910199
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20220311
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 233
IP  - 2
DP  - 2014 Jun
TI  - High-intensity exercise causes greater irisin response compared with 
      low-intensity exercise under similar energy consumption.
PG  - 135-40
AB  - Irisin is mainly released from skeletal muscle (myocytes) and promotes 
      thermogenesis by browning of the white adipose tissue. Although exercise has been 
      shown to increase irisin concentration in blood and myocytes via up-regulation 
      peroxisome proliferator receptor gamma coactivator-1alpha (PGC-1alpha) expression, the 
      influence of exercise intensity on irisin secretion remains unclear. Therefore, 
      we determined circulating irisin responses following a single bout of running at 
      different intensities. Six sedentary males underwent treadmill running under two 
      different conditions: a low-intensity (40% of VO2max) exercise trial (LIE) or a 
      high-intensity (80% of VO2max) exercise trial (HIE). The exercises in LIE and HIE 
      were lasted for 20 and 40 min, respectively. All subjects underwent the two 
      trials on separate days, and a randomized cross-over design was used. Blood 
      samples were collected before (Pre) and immediately after exercise, at 3, 6, and 
      19 h after exercise. Energy consumption during exercise did not significantly 
      differ between the two trials. HIE significantly increased blood lactate and 
      serum lactate dehydrogenase levels (P < 0.05). Compared with pre-exercise levels, 
      the irisin concentrations were elevated at 6 h (18% increase) and 19 h (23% 
      increase) after HIE, but significantly decreased after LIE. The relative irisin 
      concentrations (compared with pre-exercise levels) were significantly greater in 
      HIE than in LIE immediately after exercise, and at 6 and 19 h after exercise (P < 
      0.05). These findings suggest that irisin secretion after acute running exercise 
      is affected by exercise intensity, independent of energy consumption.
FAU - Tsuchiya, Yoshifumi
AU  - Tsuchiya Y
AD  - Graduate School of Sport and Health Science, Ritsumeikan University.
FAU - Ando, Daisuke
AU  - Ando D
FAU - Goto, Kazushige
AU  - Goto K
FAU - Kiuchi, Masataka
AU  - Kiuchi M
FAU - Yamakita, Mitsuya
AU  - Yamakita M
FAU - Koyama, Katsuhiro
AU  - Koyama K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Gases)
SB  - IM
MH  - *Energy Metabolism
MH  - *Exercise
MH  - Fibronectins/*blood
MH  - Gases/metabolism
MH  - Humans
MH  - Male
MH  - Oxygen Consumption
MH  - Time Factors
MH  - Young Adult
EDAT- 2014/06/10 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/06/10 06:00
PHST- 2014/06/10 06:00 [entrez]
PHST- 2014/06/10 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - DN/JST.JSTAGE/tjem/233.135 [pii]
AID - 10.1620/tjem.233.135 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2014 Jun;233(2):135-40. doi: 10.1620/tjem.233.135.