PMID- 24911946
OWN - NLM
STAT- MEDLINE
DCOM- 20151029
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 7
IP  - 2
DP  - 2015 Mar
TI  - Glucose series complexity at the threshold of diabetes.
PG  - 287-93
LID - 10.1111/1753-0407.12182 [doi]
AB  - BACKGROUND: One of the earliest signs of dysfunction in a complex system is the 
      simplification of its output. A well-accepted method to measure this phenomenon 
      is detrended fluctuation analysis (DFA). Herein, we evaluated the usefulness of 
      DFA at the threshold of type 2 diabetes mellitus (T2DM). METHODS: We report on 
      the clinical and glucometric characteristics of a sample of 103 patients at 
      increased risk of developing T2DM. All patients had HbA1c levels 5%-6.4% and met 
      at least one of the following criteria: body mass index (BMI) > 30 kg/m2, 
      essential hypertension or a first-degree relative with T2DM. For each patient, a 
      24-h glucose time series was obtained, and the clinical and glucometric variables 
      were compared. RESULTS: There was a significant correlation between the number of 
      National Cholesterol Education Program--Adult Treatment Panel (ATP III) metabolic 
      syndrome (MS)-defining criteria and DFA (rho = 0.231, P = 0.019), and DFA differed 
      significantly between patients meeting or not the ATP III definition of MS (1.443 
      vs. 1.399, respectively; P = 0.018). The DFA was not correlated with HbA1c. 
      Depending on how it was calculated, the area under the log(Fn) approximately log(n) curve 
      correlated with HbA1c levels or the number of MS criteria. Conventional 
      variability metrics (mean amplitude of glycemic excursions) did not differ 
      between patients complying or not with the definition of MS. CONCLUSIONS: 
      Complexity analysis is capable of detecting differences in variables related to 
      the risk of developing T2DM and could be a useful tool to study the initial 
      phases of glucoregulatory dysfunction leading to T2DM.
CI  - (c) 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley 
      Publishing Asia Pty Ltd.
FAU - Varela, Manuel
AU  - Varela M
AD  - Department of Internal Medicine, University Hospital of Mostoles, Madrid, Spain.
FAU - Rodriguez, Carmen
AU  - Rodriguez C
FAU - Vigil, Luis
AU  - Vigil L
FAU - Cirugeda, Eva
AU  - Cirugeda E
FAU - Colas, Ana
AU  - Colas A
FAU - Vargas, Borja
AU  - Vargas B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140819
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*diagnosis
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/*methods
MH  - Prognosis
MH  - Risk Factors
OTO - NOTNLM
OT  - blood glucose
OT  - metabolic syndrome X
OT  - type 2 diabetes mellitus
OT  - 关键词：血糖，X代谢综合征，2型糖尿病
EDAT- 2014/06/10 06:00
MHDA- 2015/10/30 06:00
CRDT- 2014/06/10 06:00
PHST- 2014/03/03 00:00 [received]
PHST- 2014/06/01 00:00 [accepted]
PHST- 2014/06/10 06:00 [entrez]
PHST- 2014/06/10 06:00 [pubmed]
PHST- 2015/10/30 06:00 [medline]
AID - 10.1111/1753-0407.12182 [doi]
PST - ppublish
SO  - J Diabetes. 2015 Mar;7(2):287-93. doi: 10.1111/1753-0407.12182. Epub 2014 Aug 19.