PMID- 24912526
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20151119
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 48
IP  - 4
DP  - 2014 Aug
TI  - Neutrophil/lymphocyte ratio is related to the severity of idiopathic dilated 
      cardiomyopathy.
PG  - 202-8
LID - 10.3109/14017431.2014.932922 [doi]
AB  - OBJECTIVES: The aim of this study was to assess whether NLR levels are associated 
      with echocardiographic parameters, New York Heart Association (NYHA) functional 
      class, or B- type natriuretic peptide (BNP) levels in patients with idiopathic 
      dilated cardiomyopathy (DCM). DESIGN: Eighty-seven patients with idiopathic DCM 
      were included prospectively from 2009 to 2014. Patients with acute decompensated 
      heart failure and conditions that alter the total or differential white blood 
      cell counts were excluded. Blood samples were collected before echocardiographic 
      investigation on admission. RESULTS: There was a statistically significant 
      correlation between neutrophil/lymphocyte ratio (NLR) and NYHA functional class 
      (r = 0.68, p < 0.001), BNP levels (r = 0.61, p < 0.001) and various 
      echocardiographic parameters. NLR was significantly higher in patients in NYHA 
      functional class III or IV (n = 39) than among those categorized as NYHA class I 
      or II (n = 48), (3.3 +/- 1.0 vs 2.1 +/- 0.6; p < 0.001). The NLR cutoff value 
      predicting severe chronic HF was 2.25 with 82% sensitivity and 65% specificity (p 
      < 0.001). On multivariate linear regression analysis NLR (p = 0.025), left 
      ventricular end-diastolic volume (p = 0.041) and left atrial volume index (LAVI) 
      (p = 0.001) were found to be independent positive predictors of BNP levels. 
      CONCLUSION: Neutrophil/Lymphocyte ratio is associated with the severity of 
      chronic heart failure in patients with idiopathic DCM.
FAU - Avci, Anil
AU  - Avci A
AD  - Department of Cardiology, Kartal Kosuyolu Cardiovascular Research and Training 
      Hospital , Kartal, Istanbul , Turkey.
FAU - Alizade, Elnur
AU  - Alizade E
FAU - Fidan, Serdar
AU  - Fidan S
FAU - Yesin, Mahmut
AU  - Yesin M
FAU - Guler, Yeliz
AU  - Guler Y
FAU - Kargin, Ramazan
AU  - Kargin R
FAU - Esen, Ali Metin
AU  - Esen AM
LA  - eng
PT  - Journal Article
DEP - 20140710
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Atrial Function, Left
MH  - Biomarkers/blood
MH  - Cardiomyopathy, Dilated/*blood/complications/diagnosis/physiopathology
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*blood/diagnosis/etiology/physiopathology
MH  - Humans
MH  - Linear Models
MH  - Lymphocyte Count
MH  - *Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - *Neutrophils
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - echocardiography
OT  - idiopathic dilated cardiomyopathy
OT  - inflammation
OT  - neutrophil/lymphocyte ratio
EDAT- 2014/06/11 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/11 06:00
PHST- 2014/06/11 06:00 [entrez]
PHST- 2014/06/11 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.3109/14017431.2014.932922 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2014 Aug;48(4):202-8. doi: 10.3109/14017431.2014.932922. Epub 
      2014 Jul 10.