PMID- 24913155
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20211021
IS  - 2046-4053 (Electronic)
IS  - 2046-4053 (Linking)
VI  - 3
DP  - 2014 Jun 10
TI  - Homeopathy for allergic rhinitis: protocol for a systematic review.
PG  - 59
LID - 10.1186/2046-4053-3-59 [doi]
AB  - BACKGROUND: Allergic rhinitis is a global health problem that is often treated 
      with homeopathy. The objective of this review will be to evaluate the 
      effectiveness of homeopathic treatment of allergic rhinitis. METHODS/DESIGN: The 
      authors will conduct a systematic review. We will search Medline, CENTRAL, 
      CINAHL, EMBASE, AMED, CAM-Quest, Google Scholar and reference lists of identified 
      studies up to December 2013.The review will include randomized controlled trials 
      that evaluate homeopathic treatment of allergic rhinitis. Studies with 
      participants of all ages, with acute or chronic comorbidities will be included. 
      Patients with immunodeficiency will not be included. The diagnosis will be based 
      on the published guidelines of diagnosis and classification. Studies of all 
      homeopathy modalities (clinical, complex and classical homeopathy, and isopathy) 
      will be included. We will include trials with both active controls (conventional 
      therapy, standard care) and placebo controls.The primary outcomes are: an 
      improvement of global symptoms recorded in validated daily or weekly diaries and 
      any scores from validated visual analogue scales; the total Quality of Life Score 
      (such as the Juniper RQLQ);individual symptoms scores which include any 
      appropriate measures of nasal obstruction, runny nose, sneezing, itching, and eye 
      symptoms; and number of days requiring medication. Secondary outcomes selected 
      will include serum immunoglobin E (IgE) levels, individual ocular symptoms, 
      adverse events, and the use of rescue medication.Treatment effects will be 
      measured by calculating the mean difference and the standardized mean difference 
      with 95% confidence interval (CI) for continuous data. Risk ratio or, if 
      feasible, odds ratio will be calculated with 95% CI for dichotomous data. After 
      assessing clinical and statistical heterogeneity, meta-analysis will be 
      performed, if appropriate. The individual participant will be the unit of 
      analysis. Descriptive information on missing data will be included about 
      participants missing due to drop out, whether there was intention to treat or per 
      protocol analysis and missing statistics. A number of subgroups, homeopathic 
      potency, age groups, and types of allergic rhinitis (seasonal or perennial) will 
      be analyzed. Sensitivity analysis will be performed to explore the impact of risk 
      of bias on overall treatment effect. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 
      CRD42013006741.
FAU - Banerjee, Kushal
AU  - Banerjee K
AD  - Dr, Kalyan Banerjee's Clinic, I-1691 Chittaranjan Park, New Delhi 110019, India. 
      kushal@drkbanerjee.com.
FAU - Costelloe, Ceire
AU  - Costelloe C
FAU - Mathie, Robert T
AU  - Mathie RT
FAU - Howick, Jeremy
AU  - Howick J
LA  - eng
PT  - Journal Article
DEP - 20140610
PL  - England
TA  - Syst Rev
JT  - Systematic reviews
JID - 101580575
SB  - IM
MH  - *Homeopathy/methods
MH  - Humans
MH  - Rhinitis, Allergic
MH  - Rhinitis, Allergic, Perennial/diagnosis/*therapy
MH  - Rhinitis, Allergic, Seasonal/diagnosis/therapy
MH  - Systematic Reviews as Topic
MH  - Treatment Outcome
PMC - PMC4057901
EDAT- 2014/06/11 06:00
MHDA- 2014/09/27 06:00
PMCR- 2014/06/10
CRDT- 2014/06/11 06:00
PHST- 2014/01/28 00:00 [received]
PHST- 2014/05/23 00:00 [accepted]
PHST- 2014/06/11 06:00 [entrez]
PHST- 2014/06/11 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
PHST- 2014/06/10 00:00 [pmc-release]
AID - 2046-4053-3-59 [pii]
AID - 10.1186/2046-4053-3-59 [doi]
PST - epublish
SO  - Syst Rev. 2014 Jun 10;3:59. doi: 10.1186/2046-4053-3-59.