PMID- 24913346
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20181202
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 77
IP  - 1
DP  - 2014 Jul
TI  - Influence of the BDNF Val66Met polymorphism on coping response to stress in 
      patients with advanced gastric cancer.
PG  - 76-80
LID - S0022-3999(14)00194-9 [pii]
LID - 10.1016/j.jpsychores.2014.04.008 [doi]
AB  - OBJECTIVE: Coping with cancer is an important determinant of psychological 
      morbidity, quality of life, and treatment adherence in cancer patients. The aim 
      of this study was to elucidate the association between the brain-derived 
      neurotrophic factor (BDNF) Val66Met polymorphism and coping response to stress in 
      patients diagnosed with advanced gastric cancer. METHODS: Ninety-one subjects (60 
      males, 31 females) recently diagnosed with advanced gastric cancer were 
      recruited. Coping style and distress level were examined using the Mini-Mental 
      Adjustment to Cancer (Mini-MAC) scale and Hospital Anxiety and Depression Scale, 
      and genotyping was evaluated. To examine the temporal stability of the Mini-MAC 
      scores, a 6-week follow-up evaluation was conducted in 72 patients, after 
      completion of two chemotherapy cycles. RESULTS: Coping style to cancer 
      significantly differed between the Met carriers of BDNF Val66Met and the Val/Val 
      homozygotes. The Met carriers were significantly more anxious than the Val/Val 
      homozygotes. CONCLUSION: The present findings suggest that the BDNF Val66Met 
      polymorphism may be involved in individual coping responses to cancer. The Met 
      allele of BDNF Val66Met may be predictive of an anxious coping style in patients 
      with advanced cancer.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Koh, Min Jung
AU  - Koh MJ
AD  - Department of Psychiatry, Yonsei University College of Medicine, Seoul, South 
      Korea; The Institute of Behavioral Science in Medicine, Yonsei University College 
      of Medicine, Seoul, South Korea. Electronic address: mjkoh@yuhs.ac.
FAU - Jeung, Hei-Cheul
AU  - Jeung HC
AD  - Division of Oncology, Department of Internal Medicine, Gangnam Severance 
      Hospital, Yonsei Cancer Center, Yonsei Cancer Research Institute, Yonsei 
      University College of Medicine, Seoul, South Korea. Electronic address: 
      jeunghc1123@yuhs.ac.
FAU - Namkoong, Kee
AU  - Namkoong K
AD  - Department of Psychiatry, Yonsei University College of Medicine, Seoul, South 
      Korea; The Institute of Behavioral Science in Medicine, Yonsei University College 
      of Medicine, Seoul, South Korea. Electronic address: keen@yuhs.ac.
FAU - Chung, Hyun Cheol
AU  - Chung HC
AD  - Division of Oncology, Department of Internal Medicine, Severance Hospital, Yonsei 
      Cancer Center, Yonsei University College of Medicine, Seoul, South Korea. 
      Electronic address: unchung8@yuhs.ac.
FAU - Kang, Jee In
AU  - Kang JI
AD  - Department of Psychiatry, Yonsei University College of Medicine, Seoul, South 
      Korea; The Institute of Behavioral Science in Medicine, Yonsei University College 
      of Medicine, Seoul, South Korea. Electronic address: jeeinkang@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20140505
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Adaptation, Psychological
MH  - Alleles
MH  - Anxiety/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Psychiatric Status Rating Scales
MH  - Stomach Neoplasms/drug therapy/genetics/*pathology/*psychology
OTO - NOTNLM
OT  - Anxious Preoccupation
OT  - BDNF
OT  - Cancer
OT  - Coping
OT  - Genetic association study
OT  - Psychosomatics
EDAT- 2014/06/11 06:00
MHDA- 2014/11/02 06:00
CRDT- 2014/06/11 06:00
PHST- 2014/02/03 00:00 [received]
PHST- 2014/04/25 00:00 [revised]
PHST- 2014/04/25 00:00 [accepted]
PHST- 2014/06/11 06:00 [entrez]
PHST- 2014/06/11 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
AID - S0022-3999(14)00194-9 [pii]
AID - 10.1016/j.jpsychores.2014.04.008 [doi]
PST - ppublish
SO  - J Psychosom Res. 2014 Jul;77(1):76-80. doi: 10.1016/j.jpsychores.2014.04.008. 
      Epub 2014 May 5.