PMID- 24914313
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140610
LR  - 20211021
IS  - 0973-1296 (Print)
IS  - 0976-4062 (Electronic)
IS  - 0973-1296 (Linking)
VI  - 10
IP  - Suppl 1
DP  - 2014 Jan
TI  - Antiasthmatic effects of schizandrae fructus extract in mice with asthma.
PG  - S80-5
LID - 10.4103/0973-1296.127348 [doi]
AB  - BACKGROUND: Schizandrae fructus (SF), the fruit of Schisandra chinensis, has been 
      used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular 
      disease, and as a tonic and astringent in China, Japan, and Korea. OBJECTIVE: 
      Investigation of the antiasthmatic effects of SF. MATERIALS AND METHODS: We 
      investigated the effects of SF on airway hyperresponsiveness (AHR) to 
      methacholine, production levels of antigen-specific antibodies, and 
      histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma 
      induced by repeated intranasal instillation of an antigen. RESULTS: SF lowered 
      AHR to methacholine (P < 0.05), antigen-specific immunoglobulin E (IgE) level (P 
      < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) 
      effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 
      0.01) levels, and immune cell infiltration. SF and PD did not affect the levels 
      of antigen-specific IgG1 and IgG2a antibodies. CONCLUSION: Our data suggest that 
      SF has possible application as an antiasthmatic drug. We also suggest that SF 
      could be used as a complementary or alternative medicine to glucocorticoids.
FAU - Kim, Hyungwoo
AU  - Kim H
AD  - Associate Professor, School of Korean Medicine, Pusan National University, Pusan, 
      South Korea.
FAU - Ahn, Yong-Tae
AU  - Ahn YT
AD  - Department of Biomedical Science, Kyungdong University, Goseong-gun, Gangwon-do, 
      South Korea.
FAU - Kim, Youn Sook
AU  - Kim YS
AD  - Master of Science, School of Korean Medicine, Pusan National University, Pusan, 
      South Korea.
FAU - Cho, Su In
AU  - Cho SI
AD  - Professor, School of Korean Medicine, Pusan National University, Pusan, South 
      Korea.
FAU - An, Won Gun
AU  - An WG
AD  - Professor, School of Korean Medicine, Pusan National University, Pusan, South 
      Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacogn Mag
JT  - Pharmacognosy magazine
JID - 101300403
PMC - PMC4047578
OTO - NOTNLM
OT  - Asthma
OT  - IgE
OT  - hyperresponsiveness
OT  - schizandrae fructus
COIS- Conflict of Interest: None declared.
EDAT- 2014/06/11 06:00
MHDA- 2014/06/11 06:01
PMCR- 2014/01/01
CRDT- 2014/06/11 06:00
PHST- 2013/04/25 00:00 [received]
PHST- 2013/05/01 00:00 [revised]
PHST- 2014/02/21 00:00 [accepted]
PHST- 2014/06/11 06:00 [entrez]
PHST- 2014/06/11 06:00 [pubmed]
PHST- 2014/06/11 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - PM-10-80 [pii]
AID - 10.4103/0973-1296.127348 [doi]
PST - ppublish
SO  - Pharmacogn Mag. 2014 Jan;10(Suppl 1):S80-5. doi: 10.4103/0973-1296.127348.