PMID- 24914461
OWN - NLM
STAT- MEDLINE
DCOM- 20150806
LR  - 20220331
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 271
DP  - 2014 Sep 1
TI  - Effects of curcumin on learning and memory deficits, BDNF, and ERK protein 
      expression in rats exposed to chronic unpredictable stress.
PG  - 116-21
LID - S0166-4328(14)00371-4 [pii]
LID - 10.1016/j.bbr.2014.05.068 [doi]
AB  - Accumulating evidence suggests that cognitive processes, such as learning and 
      memory, are affected in depression and antidepressant treatment may ameliorate 
      cognitive impairments. Recent studies have shown that curcumin exhibits 
      antidepressant-like effects. The aim of the present study was to determine 
      whether curcumin administration influences chronic unpredictable stress 
      (CUS)-induced cognitive deficits and explores underlying mechanisms. Male Wistar 
      rats were subjected to CUS protocol for a period of 5 weeks to induce depression. 
      The depressive-like behavior was tested using sucrose preference test, open field 
      test and Morris water maze test. Effects of curcumin on brain-derived 
      neurotrophic factor (BDNF) and extracellular signal-regulated kinase (ERK) levels 
      in the hippocampus were also examined. Chronic treatment with curcumin 
      significantly reversed the CUS-induced behavioral and cognitive parameters 
      (reduced sucrose preference and impaired learning and memory function) in 
      stressed rats. Additionally, CUS reduced hippocampal BDNF and ERK levels, while 
      curcumin effectively reversed these alterations. Taken together, our results 
      indicate that the antidepressant-like effects of curcumin in CUS rats are related 
      to its aptitude to promote BDNF and ERK in the hippocampus.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Liu, Dexiang
AU  - Liu D
AD  - Department of Medical Psychology, Shandong University School of Medicine, 44#, 
      Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: 
      liudexiang@sdu.edu.cn.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi 
      Road, Jinan, Shandong 250012, PR China.
FAU - Gao, Ze
AU  - Gao Z
AD  - School of Life Science, Shandong University, 27#, Shanda South Road, Jinan, 
      Shandong 250100, PR China.
FAU - Xie, Kai
AU  - Xie K
AD  - Department of Medical Psychology, Shandong University School of Medicine, 44#, 
      Wenhua Xi Road, Jinan, Shandong 250012, PR China.
FAU - Zhang, Qingrui
AU  - Zhang Q
AD  - Department of Medical Psychology, Shandong University School of Medicine, 44#, 
      Wenhua Xi Road, Jinan, Shandong 250012, PR China.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Department of Medical Psychology, Shandong University School of Medicine, 44#, 
      Wenhua Xi Road, Jinan, Shandong 250012, PR China.
FAU - Pang, Qi
AU  - Pang Q
AD  - Department of Neurosurgery, Shandong Provincial Hospital, Shandong University, 
      Jinan 250021, PR China. Electronic address: 1160040715@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140608
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/drug effects
MH  - Curcumin/*pharmacology
MH  - Depression/*drug therapy/psychology
MH  - Disease Models, Animal
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Food Preferences/drug effects
MH  - Hippocampus/drug effects/metabolism
MH  - Locomotion/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy/metabolism/psychology
MH  - Motor Activity/drug effects
MH  - Psychomotor Performance/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/complications/metabolism
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Chronic unpredictable stress
OT  - Cucurmin
OT  - Depression
OT  - Extracellular signal-regulated kinase (ERK)
OT  - Learning and memory
EDAT- 2014/06/11 06:00
MHDA- 2015/08/08 06:00
CRDT- 2014/06/11 06:00
PHST- 2014/03/17 00:00 [received]
PHST- 2014/05/27 00:00 [revised]
PHST- 2014/05/30 00:00 [accepted]
PHST- 2014/06/11 06:00 [entrez]
PHST- 2014/06/11 06:00 [pubmed]
PHST- 2015/08/08 06:00 [medline]
AID - S0166-4328(14)00371-4 [pii]
AID - 10.1016/j.bbr.2014.05.068 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Sep 1;271:116-21. doi: 10.1016/j.bbr.2014.05.068. Epub 2014 
      Jun 8.