PMID- 24916890 OWN - NLM STAT- MEDLINE DCOM- 20150123 LR - 20220318 IS - 1097-0215 (Electronic) IS - 0020-7136 (Linking) VI - 136 IP - 3 DP - 2015 Feb 1 TI - A prognostic classifier consisting of 17 circulating cytokines is a novel predictor of overall survival for metastatic colorectal cancer patients. PG - 584-92 LID - 10.1002/ijc.29017 [doi] AB - We aimed to determine the prognostic values of 39 circulating cytokines in Chinese patients with metastatic colorectal cancer (CRC) and to develop a novel cytokine-based prognostic classifier (CBPC) for prognostic prediction. A total of 176 patients were divided into two cohorts based on the date of first-line chemotherapy. The first 99 cases were assigned to the training cohort, and the remaining 77 cases were assigned to the validation cohort. Thirty-nine cytokines were simultaneously analyzed in the patient serum samples using multiplex bead-based Luminex technology. We used support vector machine-based methods and Cox proportional hazards models to develop a CBPC from the training cohort, which we then validated using the second patient cohort. Univariate analysis showed that FGF-2, TGFalpha, Flt-3L, GM-CSF, INFalpha2, GRO, IL-10, MCP-3, MDC, sIL-2Ralpha, IL-2, IL-7, IL-8, MCP-1, MIP-1beta, TNFalpha and VEGF were significant risk factors affecting the overall survival (OS) of both the training cohort and the validation cohort. We developed a CBPC to predict the OS of metastatic CRC patients using these 17 cytokines (sensitivity, 0.835; specificity, 0.800). In the validation cohort, the CBPC was found to have significant power in predicting the OS of metastatic CRC patients. Our study showed that there were significant associations between cytokine expression and prognosis of the patients with metastatic CRC. The CBPC that we developed includes multiple circulating cytokines and may serve as a novel screening tool for identifying metastatic CRC patients with a high risk of short OS. These high-risk individuals may also be suitable for cytokine-targeted therapies. CI - (c) 2014 UICC. FAU - Chen, Zhi-Yuan AU - Chen ZY AD - State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guang-zhou, People's Republic of China; Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China. FAU - He, Wen-Zhuo AU - He WZ FAU - Peng, Li-Xia AU - Peng LX FAU - Jia, Wei-Hua AU - Jia WH FAU - Guo, Rong-Ping AU - Guo RP FAU - Xia, Liang-Ping AU - Xia LP FAU - Qian, Chao-Nan AU - Qian CN LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140624 PL - United States TA - Int J Cancer JT - International journal of cancer JID - 0042124 RN - 0 (Cytokines) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Colorectal Neoplasms/drug therapy/immunology/*mortality/pathology MH - Cytokines/*blood MH - Female MH - Humans MH - Male MH - Middle Aged MH - Neoplasm Metastasis MH - Prognosis MH - Proportional Hazards Models OTO - NOTNLM OT - IL-8 OT - MCP-1 OT - colorectal cancer OT - cytokine OT - metastasis OT - overall survival OT - prognosis EDAT- 2014/06/12 06:00 MHDA- 2015/01/24 06:00 CRDT- 2014/06/12 06:00 PHST- 2014/01/20 00:00 [received] PHST- 2014/05/06 00:00 [revised] PHST- 2014/05/27 00:00 [accepted] PHST- 2014/06/12 06:00 [entrez] PHST- 2014/06/12 06:00 [pubmed] PHST- 2015/01/24 06:00 [medline] AID - 10.1002/ijc.29017 [doi] PST - ppublish SO - Int J Cancer. 2015 Feb 1;136(3):584-92. doi: 10.1002/ijc.29017. Epub 2014 Jun 24.