PMID- 24917427
OWN - NLM
STAT- MEDLINE
DCOM- 20160317
LR  - 20150618
IS  - 2042-3306 (Electronic)
IS  - 0425-1644 (Linking)
VI  - 47
IP  - 4
DP  - 2015 Jul
TI  - Detection of bacteraemia and host response in healthy neonatal foals.
PG  - 405-9
LID - 10.1111/evj.12307 [doi]
AB  - REASONS FOR PERFORMING THE STUDY: Neonatal sepsis is a common problem in foals 
      and is a primary cause of death in the post natal period. Transient bacteraemia 
      and subsequent host responses have not been described in the equine neonate. 
      OBJECTIVES: The primary objective of this study was to determine if transient 
      bacteraemia occurs in foals within the first 72 h of life. Additional objectives 
      included description of bacterial organisms associated with transient bacteraemia 
      and concurrent cytokine gene expression in healthy foals. STUDY DESIGN: 
      Prospective observational study in healthy foals. METHODS: Blood was aseptically 
      collected for bacterial culture from observed spontaneously born foals at birth 
      and 1, 2, 3, 4, 8, 12, 24, 48 and 72 h following birth. Samples taken at birth, 
      4, 12, 24, 48 and 72 h were analysed for interferon gamma (IFNgamma), interleukin 
      (IL)-1, IL-2, IL-6, IL-8, IL-10, IL-18 and monocyte chemotactic protein 1 (MCP1) 
      cytokine gene expression quantified by RT-PCR. RESULTS: Bacteria were cultured 
      from 9 of 70 samples submitted for blood culture. The positive samples were from 
      4 of the 7 foals, all of which remained healthy throughout and subsequent to the 
      study. All positive blood cultures were from blood samples obtained at 12 h of 
      age or earlier and IL-10 elevation coincided with positive blood cultures in 
      healthy foals. Cytokine gene expression fluctuated with age. CONCLUSIONS: 
      Positive blood cultures suggest transient bacteraemia may occur in healthy foals 
      early in the post natal period. Age corrected normal values may be necessary to 
      interpret cytokine concentration in diseased populations.
CI  - (c) 2014 EVJ Ltd.
FAU - Hackett, E S
AU  - Hackett ES
AUID- ORCID: 0000-0001-6559-9585
AD  - Department of Clinical Sciences, Colorado State University, Fort Collins, USA.
FAU - Lunn, D P
AU  - Lunn DP
AD  - College of Veterinary Medicine, North Carolina State University, Raleigh, USA.
FAU - Ferris, R A
AU  - Ferris RA
AD  - Department of Clinical Sciences, Colorado State University, Fort Collins, USA.
FAU - Horohov, D W
AU  - Horohov DW
AD  - Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, 
      University of Kentucky, Lexington, USA.
FAU - Lappin, M R
AU  - Lappin MR
AD  - Department of Clinical Sciences, Colorado State University, Fort Collins, USA.
FAU - McCue, P M
AU  - McCue PM
AD  - Department of Clinical Sciences, Colorado State University, Fort Collins, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140905
PL  - United States
TA  - Equine Vet J
JT  - Equine veterinary journal
JID - 0173320
SB  - IM
MH  - Animals
MH  - *Animals, Newborn
MH  - Bacteremia/immunology/microbiology/*veterinary
MH  - Female
MH  - Horse Diseases/immunology/*microbiology
MH  - Horses
MH  - Male
OTO - NOTNLM
OT  - horse
OT  - passive transfer
OT  - sepsis
OT  - transfer of immunity
EDAT- 2014/06/12 06:00
MHDA- 2016/03/18 06:00
CRDT- 2014/06/12 06:00
PHST- 2014/03/03 00:00 [received]
PHST- 2014/06/01 00:00 [accepted]
PHST- 2014/06/12 06:00 [entrez]
PHST- 2014/06/12 06:00 [pubmed]
PHST- 2016/03/18 06:00 [medline]
AID - 10.1111/evj.12307 [doi]
PST - ppublish
SO  - Equine Vet J. 2015 Jul;47(4):405-9. doi: 10.1111/evj.12307. Epub 2014 Sep 5.