PMID- 24917978
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140611
LR  - 20211021
IS  - 2050-6406 (Print)
IS  - 2050-6414 (Electronic)
IS  - 2050-6406 (Linking)
VI  - 1
IP  - 5
DP  - 2013 Oct
TI  - Serological testing for celiac disease in adults.
PG  - 319-25
LID - 10.1177/2050640613502788 [doi]
AB  - BACKGROUND AND AIM: We present a systematic review on the performance of 
      currently available methods for serological diagnosis of celiac disease (CD) and 
      the role of human leukocyte antigen (HLA) typing. OBJECTIVE: A literature survey 
      was conducted using PubMed, MeSH database, Web of Science as well as manual 
      searches. RESULTS: Tissue transglutaminase antibodies (tTG) (IgA) (tested in nine 
      studies) show sensitivities and specificities in the range of 0.76-0.968 and 
      0.909-0.98, and deamidated gliadin peptide (DGP) (IgA and IgG) (tested in eight 
      studies) show sensitivities and specificities in the range of 0.69-0.984 and 
      0.903-1. Endomysial antibodies (EMA) (tested in five studies) show sensitivities 
      and specificities in the range of 0.61-0.937 and 0.98-1, respectively. 
      Combination assays (tested in three studies) using DGP + tTG and DGP (IgA + IgG) 
      show sensitivities and specificities in the range of 0.87-1 and 0.8-1, 
      respectively. HLA DQ2/DQ8 may be necessary for the development of CD-HLA DQ2 in 
      particular. A possible close correlation may also exist between CD and HLA-G. 
      CONCLUSION: DGP and tTG for serological testing for CD show equivalent diagnostic 
      performance. More studies with, in particular, DGP alone and in combination with 
      tTG are necessary before a firm recommendation can be made. HLA typing to exclude 
      CD may still be controversial. It still seems premature to diagnose celiac 
      disease in adults based on serology alone.
FAU - Schyum, Astrid Collatz
AU  - Schyum AC
AD  - Gentofte Hospital HR-Research Unit and Department of Gastroenterology F, Gentofte 
      Hospital, University of Copenhagen, Copenhagen, Denmark.
FAU - Rumessen, Juri Johannes
AU  - Rumessen JJ
AD  - Gentofte Hospital HR-Research Unit and Department of Gastroenterology F, Gentofte 
      Hospital, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PL  - England
TA  - United European Gastroenterol J
JT  - United European gastroenterology journal
JID - 101606807
PMC - PMC4040770
OTO - NOTNLM
OT  - Celiac disease
OT  - HLA DQ2/DQ8
OT  - diagnosis
OT  - gliadin
OT  - serological testing
OT  - transglutaminase
EDAT- 2014/06/12 06:00
MHDA- 2014/06/12 06:01
PMCR- 2013/10/01
CRDT- 2014/06/12 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2013/08/02 00:00 [accepted]
PHST- 2014/06/12 06:00 [entrez]
PHST- 2014/06/12 06:00 [pubmed]
PHST- 2014/06/12 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 10.1177_2050640613502788 [pii]
AID - 10.1177/2050640613502788 [doi]
PST - ppublish
SO  - United European Gastroenterol J. 2013 Oct;1(5):319-25. doi: 
      10.1177/2050640613502788.