PMID- 24918531
OWN - NLM
STAT- MEDLINE
DCOM- 20150527
LR  - 20140918
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 122
IP  - 8
DP  - 2014 Sep
TI  - Fasting blood glucose at admission and survival in patients with dilated 
      cardiomyopathy: a single-center cohort study.
PG  - 457-62
LID - 10.1055/s-0034-1376966 [doi]
AB  - BACKGROUND: Recent data have suggested that impaired fasting glucose (IFG) is an 
      independent risk factor for mortality in patients with heart failure. However, 
      the prognostic indicator of elevated fasting blood glucose (FBG) such as IFG in 
      dilated cardiomyopathy (DCM) was not well understood. The purpose of this study 
      was to examine the association between IFG at admission and survival in 
      hospitalized patients with DCM. METHODS: A retrospective cohort study was 
      undertaken in 1 089 hospitalized patients with DCM in Fuwai Hospital from 
      November 2003 to September 2 011 (female 26.5%, 51.4+/-14.6 years old). Standard 
      demographics, echocardiography and routine blood samples were obtained shortly 
      after admission. The outcomes were assessed using all-cause mortality at a mean 
      follow-up of 3.5+/-2.3 years and were analyzed using Kaplan-Meier survival curve 
      (log-rank test) and Cox regression. RESULTS: The cohort consisted of 1 089 
      patients with DCM, 835 patients with normal fasting glucose (NFG, FBG<6.1 mmol/L, 
      76.7%), 113 patients with IFG (FBG 6.1-6.9 mmol/L, 10.4%), and 141 patients with 
      FBG>/=7.0 mmol/L (12.9%). Among the 1 089 patients studied, 252 (23.1%) died over a 
      mean follow-up period of 3.5+/-2.3 years. All-cause mortality rates were highest in 
      patients with FBG>/=7.0 mmol/L (31.2%), intermediate in those with IFG (24.8%), and 
      lowest in those with NFG (21.6%); a significant difference in all-cause mortality 
      rate was found among the 3 groups (log-rank chi(2)=6.715, P=0.035). After 
      adjustment for baseline variables, New York Heart Association (NYHA) functional 
      class, QRS duration, left atrium diameter, systolic blood pressure, 
      FBG>/=7.0 mmol/L, not IFG, and circulating creatinine levels were the variables 
      that remained as predictors of all-cause mortality. CONCLUSION: In the present 
      study, all-cause mortality was higher in patients with FBG>/=7.0 mmol/L compared to 
      the patients with NFG, and FBG>/= 7.0 mmol/L, not IFG, was one of predictors of 
      all-cause mortality in DCM patients.
CI  - (c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
FAU - Li, X
AU  - Li X
AD  - Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan 
      Provincial People's Hospital, Chengdu, Sichuan, China.
FAU - Jiang, R
AU  - Jiang R
AD  - Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan 
      Provincial People's Hospital, Chengdu, Sichuan, China.
FAU - Kong, H
AU  - Kong H
AD  - Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan 
      Provincial People's Hospital, Chengdu, Sichuan, China.
FAU - Shu, Y
AU  - Shu Y
AD  - Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan 
      Provincial People's Hospital, Chengdu, Sichuan, China.
FAU - Li, Q
AU  - Li Q
AD  - Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan 
      Provincial People's Hospital, Chengdu, Sichuan, China.
FAU - Hua, W
AU  - Hua W
AD  - Cardiac Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for -Cardiovascular Diseases, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140611
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*analysis
MH  - Cardiomyopathy, Dilated/*blood/*mortality
MH  - Cohort Studies
MH  - Fasting/*blood
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
EDAT- 2014/06/12 06:00
MHDA- 2015/05/28 06:00
CRDT- 2014/06/12 06:00
PHST- 2014/06/12 06:00 [entrez]
PHST- 2014/06/12 06:00 [pubmed]
PHST- 2015/05/28 06:00 [medline]
AID - 10.1055/s-0034-1376966 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2014 Sep;122(8):457-62. doi: 
      10.1055/s-0034-1376966. Epub 2014 Jun 11.