PMID- 24919717
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 1877-8755 (Electronic)
IS  - 1138-7548 (Linking)
VI  - 70
IP  - 3
DP  - 2014 Sep
TI  - Protective effects of vitamins (C and E) and melatonin co-administration on 
      hematological and hepatic functions and oxidative stress in alloxan-induced 
      diabetic rats.
PG  - 713-23
LID - 10.1007/s13105-014-0340-5 [doi]
AB  - The present study aimed to investigate the potential effects of vitamins (C and 
      E)/melatonin co-administration on the hematologic and hepatic functions and 
      oxidative stress in alloxan-induced diabetic rats. The intraperitoneal injection 
      of alloxan (120 mg/kg b.w. for 2 days) induced a significant increase of blood 
      glucose levels (hyperglycemia) associated with serious hematologic disorders 
      (P < 0.01) evidenced by the decrease in the levels of red blood cell count (RBC) 
      (-18%), hematocrit (Ht) (-18%), hemoglobin content (Hb) (-36%), mean corpuscular 
      hemoglobin (MCH) (-17%), and mean corpuscular hemoglobin concentration (MCHC) 
      (-16%). The activities of aspartate aminotransferase (AST), alanine 
      aminotransferase (ALT), lactate dehydrogenase (LDH), and the plasmatic levels of 
      total cholesterol and triglyceride contents of diabetic rats were, however, noted 
      to undergo significant increases by 42% (P < 0.01), 134% (P < 0.001), 27.5% 
      (P < 0.01), 147% (P < 0.001), and 67% (P < 0.01), respectively, as compared to 
      the control animals. Furthermore, a significant increase in malondialdehyde (MDA) 
      content and a significant decrease in superoxide dismutase (SOD), catalase (CAT), 
      and glutathione peroxidase (GPx) activities were observed in the plasma and 
      hepatic tissues of diabetic rats when compared to the controls. Interestingly, 
      the treatment with vitamins (C, E) in combination with melatonin was noted to 
      reduce the plasma levels of glucose, lower the MDA levels, and restore the 
      hematologic parameters and biochemical and antioxidant levels of diabetic rats 
      back to normal values, alleviating diabetes metabolic disorders in rats.
FAU - Allagui, Mohamed Salah
AU  - Allagui MS
AD  - Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018, Sfax, 
      Tunisia, amsallagui@yahoo.fr.
FAU - Feriani, Anouer
AU  - Feriani A
FAU - Bouoni, Zouhour
AU  - Bouoni Z
FAU - Alimi, Hichem
AU  - Alimi H
FAU - Murat, Jean Claud
AU  - Murat JC
FAU - El Feki, Abdelfattah
AU  - El Feki A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140613
PL  - Spain
TA  - J Physiol Biochem
JT  - Journal of physiology and biochemistry
JID - 9812509
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 1406-18-4 (Vitamin E)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - JL5DK93RCL (Melatonin)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Ascorbic Acid/*administration & dosage
MH  - Aspartate Aminotransferases/blood
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/metabolism
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Lipids/blood
MH  - Liver/drug effects/metabolism/pathology
MH  - Male
MH  - Malondialdehyde/blood/metabolism
MH  - Melatonin/*administration & dosage
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Vitamin E/*administration & dosage
EDAT- 2014/06/13 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/06/13 06:00
PHST- 2013/12/05 00:00 [received]
PHST- 2014/06/03 00:00 [accepted]
PHST- 2014/06/13 06:00 [entrez]
PHST- 2014/06/13 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1007/s13105-014-0340-5 [doi]
PST - ppublish
SO  - J Physiol Biochem. 2014 Sep;70(3):713-23. doi: 10.1007/s13105-014-0340-5. Epub 
      2014 Jun 13.