PMID- 24920291
OWN - NLM
STAT- MEDLINE
DCOM- 20140922
LR  - 20161018
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 171
IP  - 3
DP  - 2014 Sep
TI  - Association between the p27 rs2066827 variant and tumor multiplicity in patients 
      harboring MEN1 germline mutations.
PG  - 335-42
LID - 10.1530/EJE-14-0130 [doi]
AB  - OBJECTIVE: To date, no evidence of robust genotype-phenotype correlation or 
      disease modifiers for multiple endocrine neoplasia type 1 (MEN1) syndrome has 
      been described, leaving the highly variable clinical presentation of patients 
      unaccounted for. DESIGN: As the CDKN1B (p27) gene causes MEN4 syndrome and it is 
      transcriptionally regulated by the product of the MEN1 gene (menin), we sought to 
      analyze whether p27 influences the phenotype of MEN1-mutated patients. The cohort 
      consisted of 100 patients carrying germline MEN1 gene mutations and 855 
      population-matched control individuals. METHODS: Genotyping of the coding p27 
      c.326T>G (V109G) variant was performed by sequencing and restriction site 
      digestion, and the genotypes were associated with clinical parameters by 
      calculating odds ratios (ORs) and their 95% CIs using logistic regression. 
      RESULTS: There were significant differences in p27 V109G allele frequencies 
      between controls and MEN1-mutated patients (OR=2.55, P=0.019, CI=1.013-5.76). 
      Among patients who are >/=30 years old carrying truncating MEN1 mutations, the T 
      allele was strongly associated with susceptibility to tumors in multiple glands 
      (three to four glands affected vs one to two glands affected; OR=18.33; P=0.002, 
      CI=2.88-16.41). This finding remained significant after the Bonferroni's multiple 
      testing correction, indicating a robust association. No correlations were 
      observed with the development of MEN1-related tumors such as hyperparathyroidism, 
      pituitary adenomas, and enteropancreatic and adrenocortical tumors. CONCLUSIONS: 
      Our study suggests that the p27 tumor suppressor gene acts as a disease modifier 
      for the MEN1 syndrome associated with MEN1 germline mutations. If confirmed in 
      independent patient cohorts, this finding could facilitate the management of this 
      clinically complex disease.
CI  - (c) 2014 European Society of Endocrinology.
FAU - Longuini, Viviane C
AU  - Longuini VC
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Lourenco, Delmar M Jr
AU  - Lourenco DM Jr
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Sekiya, Tomoko
AU  - Sekiya T
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Meirelles, Osorio
AU  - Meirelles O
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Goncalves, Tatiana D
AU  - Goncalves TD
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Coutinho, Flavia L
AU  - Coutinho FL
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Francisco, Guilherme
AU  - Francisco G
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Osaki, Luciana H
AU  - Osaki LH
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Chammas, Roger
AU  - Chammas R
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Alves, Venancio A F
AU  - Alves VA
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Siqueira, Sheila A C
AU  - Siqueira SA
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Schlesinger, David
AU  - Schlesinger D
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, 
      BrazilEndocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Naslavsky, Michel S
AU  - Naslavsky MS
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Zatz, Mayana
AU  - Zatz M
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Duarte, Yeda A O
AU  - Duarte YA
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Lebrao, Maria Lucia
AU  - Lebrao ML
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Gama, Patricia
AU  - Gama P
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Lee, Misu
AU  - Lee M
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Molatore, Sara
AU  - Molatore S
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Pereira, Maria Adelaide A
AU  - Pereira MA
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Jallad, Raquel S
AU  - Jallad RS
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Bronstein, Marcello D
AU  - Bronstein MD
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Cunha-Neto, Malebranche B
AU  - Cunha-Neto MB
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Liberman, Bernardo
AU  - Liberman B
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Fragoso, Maria Candida B V
AU  - Fragoso MC
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Toledo, Sergio P A
AU  - Toledo SP
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, 
      BrazilEndocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Pellegata, Natalia S
AU  - Pellegata NS
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil.
FAU - Toledo, Rodrigo A
AU  - Toledo RA
AD  - Endocrine Genetics Unit (Laboratorio de Investigacao 
      Medica/LIM-25)Neuroendocrinology UnitNeuroendocrinology-Neurosurgery UnitAdrenal 
      Unit (LIM-42)General Endocrinology UnitExperimental Oncology Laboratory 
      (LIM-24)Department of PathologyNursing SchoolSchool of Public Health of Hospital 
      das ClinicasUniversity of Sao Paulo School of Medicine, Sao Paulo, 
      BrazilBrigadeiro HospitalSao Paulo, BrazilHuman Genome Research CenterUniversity 
      of Sao Paulo, Sao Paulo, BrazilInstituto do CerebroInstituto Israelita de Ensino 
      e Pesquisa Albert Einstein, Sao Paulo, BrazilNational Institute of AgingNational 
      Institutes of Health (NIH), Bethesda, Maryland, USAInstitute of 
      PathologyHelmholtz Zentrum Munchen, Neuherberg, GermanyInstitute of Biomedical 
      SciencesUniversity of Sao Paulo, Sao Paulo, BrazilDivision of 
      EndocrinologyFederal University of Sao Paulo (UNIFESP), Sao Paulo, Brazil 
      toledorodrigo@usp.br toledorodrigo79@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140611
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Cyclin-Dependent Kinase Inhibitor p27/*genetics
MH  - Female
MH  - Genetic Association Studies/*methods
MH  - Genetic Variation/*genetics
MH  - Germ-Line Mutation/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - Young Adult
EDAT- 2014/06/13 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/06/13 06:00
PHST- 2014/06/13 06:00 [entrez]
PHST- 2014/06/13 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - EJE-14-0130 [pii]
AID - 10.1530/EJE-14-0130 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2014 Sep;171(3):335-42. doi: 10.1530/EJE-14-0130. Epub 2014 Jun 
      11.