PMID- 24920333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 26
IP  - 6
DP  - 2014 Jun
TI  - The Chromatin-Remodeling Factor PICKLE Integrates Brassinosteroid and Gibberellin 
      Signaling during Skotomorphogenic Growth in Arabidopsis.
PG  - 2472-2485
AB  - Plant cell elongation is controlled by endogenous hormones, including 
      brassinosteroid (BR) and gibberellin (GA), and by environmental factors, such as 
      light/darkness. The molecular mechanisms underlying the convergence of these 
      signals that govern cell growth remain largely unknown. We previously showed that 
      the chromatin-remodeling factor PICKLE/ENHANCED PHOTOMORPHOGENIC1 (PKL/EPP1) 
      represses photomorphogenesis in Arabidopsis thaliana. Here, we demonstrated that 
      PKL physically interacted with PHYTOCHROME-INTERACTING FACTOR3 (PIF3) and 
      BRASSINAZOLE-RESISTANT1 (BZR1), key components of the light and BR signaling 
      pathways, respectively. Also, this interaction promoted the association of PKL 
      with cell elongation-related genes. We found that PKL, PIF3, and BZR1 coregulate 
      skotomorphogenesis by repressing the trimethylation of histone H3 Lys-27 
      (H3K27me3) on target promoters. Moreover, DELLA proteins interacted with PKL and 
      attenuated its binding ability. Strikingly, brassinolide and GA(3) inhibited 
      H3K27me3 modification of histones associated with cell elongation-related loci in 
      a BZR1- and DELLA-mediated manner, respectively. Our findings reveal that the PKL 
      chromatin-remodeling factor acts as a critical node that integrates 
      light/darkness, BR, and GA signals to epigenetically regulate plant growth and 
      development. This work also provides a molecular framework by which hormone 
      signals regulate histone modification in concert with light/dark environmental 
      cues.
CI  - (c) 2014 American Society of Plant Biologists. All rights reserved.
FAU - Zhang, Dong
AU  - Zhang D
AD  - Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, 
      Beijing 100093, China University of the Chinese Academy of Sciences, Beijing 
      100049, China.
FAU - Jing, Yanjun
AU  - Jing Y
AD  - Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, 
      Beijing 100093, China.
FAU - Jiang, Zhimin
AU  - Jiang Z
AD  - Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, 
      Beijing 100093, China University of the Chinese Academy of Sciences, Beijing 
      100049, China.
FAU - Lin, Rongcheng
AU  - Lin R
AUID- ORCID: 0000-0001-8346-3390
AD  - Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, 
      Beijing 100093, China National Center for Plant Gene Research, Beijing 100093, 
      China rclin@ibcas.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20140610
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
PMC - PMC4114946
EDAT- 2014/06/13 06:00
MHDA- 2014/06/13 06:01
PMCR- 2015/06/01
CRDT- 2014/06/13 06:00
PHST- 2014/06/13 06:00 [entrez]
PHST- 2014/06/13 06:00 [pubmed]
PHST- 2014/06/13 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - tpc.113.121848 [pii]
AID - 121848 [pii]
AID - 10.1105/tpc.113.121848 [doi]
PST - ppublish
SO  - Plant Cell. 2014 Jun;26(6):2472-2485. doi: 10.1105/tpc.113.121848. Epub 2014 Jun 
      10.