PMID- 24920721
OWN - NLM
STAT- MEDLINE
DCOM- 20150320
LR  - 20220321
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 130
IP  - 7
DP  - 2014 Aug 12
TI  - Epigenome-wide association study of fasting blood lipids in the Genetics of 
      Lipid-lowering Drugs and Diet Network study.
PG  - 565-72
LID - 10.1161/CIRCULATIONAHA.114.009158 [doi]
AB  - BACKGROUND: Genetic research regarding blood lipids has largely focused on DNA 
      sequence variation; few studies have explored epigenetic effects. Genome-wide 
      surveys of DNA methylation may uncover epigenetic factors influencing lipid 
      metabolism. METHODS AND RESULTS: To identify whether differential methylation of 
      cytosine-(phosphate)-guanine dinucleotides (CpGs) correlated with lipid 
      phenotypes, we isolated DNA from CD4+ T cells and quantified the proportion of 
      sample methylation at >450 000 CpGs by using the Illumina Infinium 
      HumanMethylation450 Beadchip in 991 participants of the Genetics of Lipid 
      Lowering Drugs and Diet Network. We modeled the percentage of methylation at 
      individual CpGs as a function of fasting very-low-density lipoprotein cholesterol 
      and triglycerides (TGs) by using mixed linear regression adjusted for age, sex, 
      study site, cell purity, and family structure. Four CpGs (cg00574958, cg17058475, 
      cg01082498, and cg09737197) in intron 1 of carnitine palmitoyltransferase 1A 
      (CPT1A) were strongly associated with very-low low-density lipoprotein 
      cholesterol (P=1.8x10(-21) to 1.6x10(-8)) and TG (P=1.6x10(-26) to 1.5x10(-9)). 
      Array findings were validated by bisulfite sequencing. We performed quantitative 
      polymerase chain reaction experiments demonstrating that methylation of the top 
      CpG (cg00574958) was correlated with CPT1A expression. The association of 
      cg00574958 with TG and CPT1A expression were replicated in the Framingham Heart 
      Study (P=4.1x10(-14) and 3.1x10(-13), respectively). DNA methylation at CPT1A 
      cg00574958 explained 11.6% and 5.5% of the variation in TG in the discovery and 
      replication cohorts, respectively. CONCLUSIONS: This genome-wide epigenomic study 
      identified CPT1A methylation as strongly and robustly associated with fasting 
      very-low low-density lipoprotein cholesterol and TG. Identifying novel epigenetic 
      contributions to lipid traits may inform future efforts to identify new treatment 
      targets and biomarkers of disease risk.
CI  - (c) 2014 American Heart Association, Inc.
FAU - Irvin, Marguerite R
AU  - Irvin MR
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.). irvinr@uab.edu.
FAU - Zhi, Degui
AU  - Zhi D
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Joehanes, Roby
AU  - Joehanes R
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Mendelson, Michael
AU  - Mendelson M
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Aslibekyan, Stella
AU  - Aslibekyan S
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Claas, Steven A
AU  - Claas SA
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Thibeault, Krista S
AU  - Thibeault KS
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Patel, Nikita
AU  - Patel N
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Day, Kenneth
AU  - Day K
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Jones, Lindsay Waite
AU  - Jones LW
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Liang, Liming
AU  - Liang L
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Chen, Brian H
AU  - Chen BH
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Yao, Chen
AU  - Yao C
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Tiwari, Hemant K
AU  - Tiwari HK
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Ordovas, Jose M
AU  - Ordovas JM
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Levy, Daniel
AU  - Levy D
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Absher, Devin
AU  - Absher D
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
FAU - Arnett, Donna K
AU  - Arnett DK
AD  - From the Department of Epidemiology, School of Public Health, University of 
      Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department 
      of Biostatistics, Section on Statistical Genetics, University of Alabama at 
      Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National 
      Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA 
      (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston 
      Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, 
      Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and 
      Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); 
      and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research 
      Center on Aging at Tufts University, Boston, MA (J.M.O.).
LA  - eng
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
GR  - R01 HL104135/HL/NHLBI NIH HHS/United States
GR  - R01 HL091357/HL/NHLBI NIH HHS/United States
GR  - R01 HL104135-01/HL/NHLBI NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20140611
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Triglycerides)
RN  - EC 2.3.1.21 (CPT1A protein, human)
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
SB  - IM
MH  - Adult
MH  - Anticholesteremic Agents/pharmacology/therapeutic use
MH  - Carnitine O-Palmitoyltransferase/blood/*genetics
MH  - Cohort Studies
MH  - Epigenomics/*methods
MH  - *Fasting/blood
MH  - Female
MH  - Genome-Wide Association Study/*methods
MH  - Humans
MH  - Lipoproteins, VLDL/blood/*genetics
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/blood/*genetics
PMC - PMC4209699
MID - NIHMS602656
OTO - NOTNLM
OT  - cholesterol
OT  - fatty acids
OT  - genetics, medical
OT  - lipids
OT  - lipoproteins
COIS- Conflict of Interest Disclosures: None.
EDAT- 2014/06/13 06:00
MHDA- 2015/03/21 06:00
PMCR- 2015/08/12
CRDT- 2014/06/13 06:00
PHST- 2014/06/13 06:00 [entrez]
PHST- 2014/06/13 06:00 [pubmed]
PHST- 2015/03/21 06:00 [medline]
PHST- 2015/08/12 00:00 [pmc-release]
AID - CIRCULATIONAHA.114.009158 [pii]
AID - 10.1161/CIRCULATIONAHA.114.009158 [doi]
PST - ppublish
SO  - Circulation. 2014 Aug 12;130(7):565-72. doi: 10.1161/CIRCULATIONAHA.114.009158. 
      Epub 2014 Jun 11.