PMID- 24923289
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20171116
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 82
IP  - 1
DP  - 2014
TI  - Predictors of metabolic risk in childhood obesity.
PG  - 3-11
LID - 10.1159/000362237 [doi]
AB  - Most of the complications of juvenile obesity are due to metabolic disturbances 
      induced by an excessive accumulation of fat which leads to chronic diseases like 
      type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Finding 
      effective ways of identifying obese paediatric patients who are at increased risk 
      of developing cardiovascular and metabolic complications has been recognised to 
      be a promising strategy to improve prevention of complications of early obesity. 
      Moreover, correctly identifying obese children who are already affected by 
      metabolic co-morbidities should be a clinical priority. According to the state of 
      the art summarised in this review, traditional metabolic variables included in 
      the definitions of metabolic syndrome (MS), pre-diabetes, non-alcoholic fatty 
      liver disease (NAFLD)/non-alcoholic steato-hepatitis and, in obese girls, the 
      presence of polycystic ovary syndrome are the best available longitudinal 
      predictors of CVD and T2DM among obese children and adolescents. In clinical 
      practice, traditional metabolic variables included in the definitions of MS 
      should be assessed in all obese children and adolescents; fasting metabolic 
      variables have been proposed to identify obese patients likely to be affected by 
      impaired glucose tolerance or T2DM, and ultrasound has proved to be a valid 
      surrogate for biopsy in the diagnosis of NAFLD. Further large longitudinal and 
      cross-sectional studies are needed to improve our chances of identifying obese 
      youth at the highest metabolic risk.
FAU - Morandi, Anita
AU  - Morandi A
AD  - Regional Centre for Pediatric Diabetes, Clinical Nutrition and Obesity, ULSS 20, 
      and University of Verona, Verona, Italy.
FAU - Maffeis, Claudio
AU  - Maffeis C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140611
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
SB  - IM
MH  - Adolescent
MH  - *Cardiovascular Diseases/etiology/metabolism/pathology
MH  - Child
MH  - Child, Preschool
MH  - *Diabetes Mellitus, Type 2/etiology/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Metabolic Syndrome/etiology/metabolism/pathology
MH  - *Non-alcoholic Fatty Liver Disease/etiology/metabolism/pathology
MH  - *Obesity/complications/metabolism/pathology
MH  - Risk Factors
EDAT- 2014/06/14 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/14 06:00
PHST- 2013/12/31 00:00 [received]
PHST- 2014/03/14 00:00 [accepted]
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 000362237 [pii]
AID - 10.1159/000362237 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2014;82(1):3-11. doi: 10.1159/000362237. Epub 2014 Jun 11.