PMID- 24923584
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20211021
IS  - 1867-108X (Electronic)
IS  - 1867-1071 (Linking)
VI  - 32
IP  - 9
DP  - 2014 Sep
TI  - Efficacy of preoperative transcatheter arterial chemoembolization combined with 
      systemic chemotherapy for treatment of unresectable hepatoblastoma in children.
PG  - 529-36
LID - 10.1007/s11604-014-0340-y [doi]
AB  - PURPOSE: The purpose of this study was to evaluate, retrospectively, the clinical 
      efficacy of preoperative transcatheter arterial chemoembolization (TACE) combined 
      with systemic chemotherapy for unresectable hepatoblastoma. MATERIALS AND 
      METHODS: Five boys and three girls (mean age 15.2 months) were treated with 
      preoperative TACE combined with systemic chemotherapy for unresectable 
      hepatoblastomas. Mean tumor diameter and mean alfa-fetoprotein (AFP) level were 
      11.8 cm and 549,386 ng/mL, respectively. Pretreatment, the extent of disease 
      (PRETEXT) was: II, 1; III, 6; IV, 1. For all patients, preoperative systemic 
      chemotherapy was administered before TACE. At each TACE, carboplatin and 
      adriamycin mixed with iodized oil were infused into the feeding arteries. Tumor 
      response and prognosis after treatment were evaluated. RESULTS: TACE resulted in 
      few Grade 1 adverse effects (AEs), without G3 or more AEs, according to CTACAE 
      3.0. Mean tumor shrinkage was 60.9%, and the mean AFP decrease from initial 
      levels was 94.8%. In all cases TACE combined with systemic chemotherapy enabled 
      subsequent safe and complete surgical resection. After a mean follow-up of 59 
      months, tumor-free survival was 75%. CONCLUSION: Preoperative TACE combined with 
      systemic chemotherapy was effective in inducing surgical resectability of 
      unresectable hepatoblastoma.
FAU - Hirakawa, Masakazu
AU  - Hirakawa M
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan, 
      mahira@radiol.med.kyushu-u.ac.jp.
FAU - Nishie, Akihiro
AU  - Nishie A
FAU - Asayama, Yoshiki
AU  - Asayama Y
FAU - Fujita, Nobuhiro
AU  - Fujita N
FAU - Ishigami, Kousei
AU  - Ishigami K
FAU - Tajiri, Tatsurou
AU  - Tajiri T
FAU - Taguchi, Tomoaki
AU  - Taguchi T
FAU - Honda, Hiroshi
AU  - Honda H
LA  - eng
PT  - Journal Article
DEP - 20140613
PL  - Japan
TA  - Jpn J Radiol
JT  - Japanese journal of radiology
JID - 101490689
RN  - 8001-40-9 (Iodized Oil)
RN  - 80168379AG (Doxorubicin)
RN  - BG3F62OND5 (Carboplatin)
SB  - IM
MH  - Carboplatin/administration & dosage
MH  - Chemoembolization, Therapeutic/*methods
MH  - Child, Preschool
MH  - Combined Modality Therapy/methods
MH  - Doxorubicin/administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Hepatoblastoma/drug therapy/*therapy
MH  - Humans
MH  - Infant
MH  - Iodized Oil/administration & dosage
MH  - Liver Neoplasms/drug therapy/*therapy
MH  - Male
MH  - Preoperative Care/*methods
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2014/06/14 06:00
MHDA- 2015/06/05 06:00
CRDT- 2014/06/14 06:00
PHST- 2014/02/26 00:00 [received]
PHST- 2014/06/03 00:00 [accepted]
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
AID - 10.1007/s11604-014-0340-y [doi]
PST - ppublish
SO  - Jpn J Radiol. 2014 Sep;32(9):529-36. doi: 10.1007/s11604-014-0340-y. Epub 2014 
      Jun 13.