PMID- 24924404 OWN - NLM STAT- MEDLINE DCOM- 20150526 LR - 20240321 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 158 IP - 1-3 DP - 2014 Sep TI - Frequency and pattern of childhood symptom onset reported by first episode schizophrenia and clinical high risk youth. PG - 45-51 LID - S0920-9964(14)00247-3 [pii] LID - 10.1016/j.schres.2014.05.017 [doi] AB - BACKGROUND: Psychosis prevention and early intervention efforts in schizophrenia have focused increasingly on sub-threshold psychotic symptoms in adolescents and young adults. Although many youth report symptom onset prior to adolescence, the childhood incidence of prodromal-level symptoms in those with schizophrenia or related psychoses is largely unknown. METHODS: This study reports on the retrospective recall of prodromal-level symptoms from 40 participants in a first-episode of schizophrenia (FES) and 40 participants at "clinical high risk" (CHR) for psychosis. Onset of positive and non-specific symptoms was captured using the Structured Interview for Prodromal Syndromes. Frequencies are reported according to onset during childhood (prior to age 13), adolescence (13-17), or adulthood (18+). RESULTS: Childhood-onset of attenuated psychotic symptoms was not rare. At least 11% of FES and 23% of CHR reported specific recall of childhood-onset of unusual or delusional ideas, suspiciousness, or perceptual abnormalities. Most recalled experiencing non-specific symptoms prior to positive symptoms. CHR and FES did not differ significantly in the timing of positive and non-specific symptom onset. Other than being younger at assessment, those with childhood onset did not differ demographically from those with later onset. CONCLUSION: Childhood-onset of initial psychotic-like symptoms may be more common than previous research has suggested. Improved characterization of these symptoms and a focus on their predictive value for subsequent schizophrenia and other major psychoses are needed to facilitate screening of children presenting with attenuated psychotic symptoms. Accurate detection of prodromal symptoms in children might facilitate even earlier intervention and the potential to alter pre-illness trajectories. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Woodberry, Kristen A AU - Woodberry KA AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. Electronic address: kwoodber@bidmc.harvard.edu. FAU - Serur, Rachael A AU - Serur RA AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States. FAU - Hallinan, Sean B AU - Hallinan SB AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States. FAU - Mesholam-Gately, Raquelle I AU - Mesholam-Gately RI AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Giuliano, Anthony J AU - Giuliano AJ AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Department of Psychology, Worcester Recovery Center and Hospital, Worcester, MA, United States. FAU - Wojcik, Joanne D AU - Wojcik JD AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Keshavan, Matcheri S AU - Keshavan MS AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Frazier, Jean A AU - Frazier JA AD - Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, United States; University of Massachusetts Memorial Health Care, Worcester, MA, United States. FAU - Goldstein, Jill M AU - Goldstein JM AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States; Department of Medicine, Brigham and Women's Hospital, Division of Women's Health, Connors Center for Women's Health and Gender Biology, Boston, MA, United States; Department of Medicine, Harvard Medical School, Boston, MA, United States; Department of Psychiatry, Division of Psychiatric Neuroscience, Massachusetts General Hospital, Boston, MA, United States. FAU - Shenton, Martha E AU - Shenton ME AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; Department of Radiology, Harvard Medical School, Boston, MA, United States; Veterans Affairs Boston Healthcare System, Brockton, MA, United States; Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States. FAU - McCarley, Robert W AU - McCarley RW AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States; Veterans Affairs Boston Healthcare System, Brockton, MA, United States. FAU - Seidman, Larry J AU - Seidman LJ AD - Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. LA - eng GR - UL1RR025758/RR/NCRR NIH HHS/United States GR - P30HD0004147/HD/NICHD NIH HHS/United States GR - M01 RR001032/RR/NCRR NIH HHS/United States GR - UO1 MH081928/MH/NIMH NIH HHS/United States GR - S10 RR023043/RR/NCRR NIH HHS/United States GR - S10 RR019307/RR/NCRR NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - P41 RR014075/RR/NCRR NIH HHS/United States GR - P30 HD004147/HD/NICHD NIH HHS/United States GR - 1S10RR019307/RR/NCRR NIH HHS/United States GR - 1S10RR023043/RR/NCRR NIH HHS/United States GR - 1S10RR023401/RR/NCRR NIH HHS/United States GR - M01RR01032/RR/NCRR NIH HHS/United States GR - UL1 RR025758/RR/NCRR NIH HHS/United States GR - P50 MH 080272/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - S10 RR023401/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20140610 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Adult MH - Age of Onset MH - Female MH - Humans MH - Interview, Psychological MH - Male MH - Mental Recall MH - Middle Aged MH - *Prodromal Symptoms MH - Retrospective Studies MH - Risk MH - Schizophrenia/*epidemiology MH - *Schizophrenic Psychology MH - Self Report MH - Young Adult PMC - PMC4207713 MID - NIHMS604788 OTO - NOTNLM OT - Child OT - Early onset OT - Prodrome OT - Psychosis OT - Psychotic-like OT - SIPS COIS- Conflict of interest J.A.F. has received research support from Glaxo Smith Kline, Pfizer, Inc., Neuren, Roche, and Seaside Therapeutics. She serves on a data safety monitoring board for a Forest Pharmaceuticals study. All other authors deny conflicts of interest in relation to the subject of this study. EDAT- 2014/06/14 06:00 MHDA- 2015/05/27 06:00 PMCR- 2015/09/01 CRDT- 2014/06/14 06:00 PHST- 2014/01/07 00:00 [received] PHST- 2014/05/13 00:00 [revised] PHST- 2014/05/16 00:00 [accepted] PHST- 2014/06/14 06:00 [entrez] PHST- 2014/06/14 06:00 [pubmed] PHST- 2015/05/27 06:00 [medline] PHST- 2015/09/01 00:00 [pmc-release] AID - S0920-9964(14)00247-3 [pii] AID - 10.1016/j.schres.2014.05.017 [doi] PST - ppublish SO - Schizophr Res. 2014 Sep;158(1-3):45-51. doi: 10.1016/j.schres.2014.05.017. Epub 2014 Jun 10.