PMID- 24925249
OWN - NLM
STAT- MEDLINE
DCOM- 20151102
LR  - 20161125
IS  - 1618-1433 (Electronic)
IS  - 0940-2993 (Linking)
VI  - 66
IP  - 8
DP  - 2014 Oct
TI  - The effects of grape seed and colchicine on carbon tetrachloride induced hepatic 
      damage in rats.
PG  - 361-5
LID - S0940-2993(14)00067-0 [pii]
LID - 10.1016/j.etp.2014.04.008 [doi]
AB  - This study aims to determine the effects of grape seed and colchicine on carbon 
      tetrachloride (CCl4) induced hepatic damage and on some serum biochemical 
      parameters. Sixty male Wistar albino rats (200-250 g) were randomly divided into 
      six groups (ten rats/group) and included the control group the group were given 
      isotonic sodium chloride (1 mL/kg b.w) intraperitonealy (i.p.), group 2 the group 
      treated i.p. injection of CCl4 (1.0 mL/kg b.w) in corn oil twice in the first 
      week, Groups 3 and 4 injected with CCl4 as described for group 2 and the rats 
      were orally given (100 mg/kg b.w) GSE and i.p. injected (10 mug/rat) with 
      colchicine for four weeks, respectively and groups 5 and 6 were the grape seed 
      and colchicine control groups in which rats were orally given grape seed (100 
      mg/kg b.w) and i.p. injected with colchicine (10 mug/rat), respectively. Anorexia, 
      weight loss, motionlessness and hepatic colour variation at necropsy were 
      observed in groups 2, 3, and 4. Hyperemia, focal bleeding, fat degeneration, 
      changes ranging from degenerative to necrotic, increase in connective tissue 
      elements, pronounced in portal sites in particular, and infiltration of lymphoid 
      series cell observed in the livers of the rats in group 2, treated with CCl4. 
      Histological hepatic changes in the rats in group 3 and 4 were similar to those 
      in group 2. The levels of serum total protein, albumin and globulin decreased in 
      groups 2, 3, and 4, compared with groups 1, 5 and 6; aspartate transaminase (ALT) 
      activities increased. The lowest alkaline phosphatase (ALP) activities were in 
      groups 4 and 5. We concluded that GSE and colchicine have not sufficient 
      ameliorative effects to CCl4 induced acute hepatic damage.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Atasever, Ayhan
AU  - Atasever A
AD  - Erciyes University Faculty of Veterinary Medicine, Department of Pathology, 
      Kayseri, Turkey.
FAU - Yaman, Duygu
AU  - Yaman D
AD  - Erciyes University Faculty of Veterinary Medicine, Department of Pathology, 
      Kayseri, Turkey. Electronic address: dyguyaman@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140610
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
RN  - 0 (Antioxidants)
RN  - 0 (Grape Seed Extract)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Animals
MH  - Antioxidants
MH  - Carbon Tetrachloride/toxicity
MH  - Chemical and Drug Induced Liver Injury
MH  - Colchicine/*pharmacology
MH  - Disease Models, Animal
MH  - Grape Seed Extract/*pharmacology
MH  - Liver/drug effects/metabolism/pathology
MH  - Liver Diseases/metabolism/*pathology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Carbon tetrachloride
OT  - Colchicine
OT  - Grape seed
OT  - Liver
OT  - Rat
EDAT- 2014/06/14 06:00
MHDA- 2015/11/03 06:00
CRDT- 2014/06/14 06:00
PHST- 2014/02/14 00:00 [received]
PHST- 2014/04/26 00:00 [revised]
PHST- 2014/04/29 00:00 [accepted]
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2015/11/03 06:00 [medline]
AID - S0940-2993(14)00067-0 [pii]
AID - 10.1016/j.etp.2014.04.008 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 2014 Oct;66(8):361-5. doi: 10.1016/j.etp.2014.04.008. Epub 
      2014 Jun 10.