PMID- 24925397
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140613
IS  - 1662-2898 (Electronic)
IS  - 0079-6034 (Linking)
VI  - 100
DP  - 2014
TI  - Mast cell research.
PG  - 165-71
LID - 10.1159/000358733 [doi]
AB  - The role of mast cells in allergy remained unrevealed until the observation that 
      they contained histamine in 1953, and then the discovery of immunoglobulin E 
      (IgE) in 1966, nearly a century after Ehrlich's first publication. After the 
      discovery of IgE, myeloma-derived IgE from Peter Shackford, who made a great 
      contribution to mankind by providing 40 liters of plasma in the year prior to his 
      death, was distributed to many researchers. This accelerated the exploration of 
      the mechanisms involved in allergic reactions, especially regarding the role of 
      mast cells in IgE-mediated reactions. The identification of mast cells as a 
      progeny of a bone marrow hematopoietic stem cell in 1977 led us to the successful 
      in vitro culture of mast cells. Along with the development of molecular 
      biological techniques, the structure of the high-affinity IgE receptor (FcepsilonRI) 
      was determined in 1989. Thus, we now understand the whole molecules the 
      expression of which is changed when mast cells are activated via FcepsilonRI 
      cross-linking. However, the physiological and pathological roles of mast cells, 
      especially where IgE is not involved, are not yet fully understood. It will be 
      necessary to determine the mechanisms involved in the 'non-IgE-mediated' steps of 
      mast cell activation in allergic or other diseases.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Saito, Hirohisa
AU  - Saito H
AD  - National Research Institute for Child Health and Development, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140522
PL  - Switzerland
TA  - Chem Immunol Allergy
JT  - Chemical immunology and allergy
JID - 101183835
RN  - 0 (Cytokines)
RN  - 0 (Receptors, IgE)
RN  - 0 (Stem Cell Factor)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Hematopoietic Stem Cells/cytology/metabolism
MH  - Histamine/metabolism
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Mast Cells/immunology/*metabolism
MH  - Mice
MH  - Phenotype
MH  - Receptors, IgE/metabolism
MH  - Stem Cell Factor/metabolism
EDAT- 2014/06/14 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/06/14 06:00
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 000358733 [pii]
AID - 10.1159/000358733 [doi]
PST - ppublish
SO  - Chem Immunol Allergy. 2014;100:165-71. doi: 10.1159/000358733. Epub 2014 May 22.