PMID- 24925604
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20140721
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 29
IP  - 8
DP  - 2014 Jul
TI  - BDNF Val66Met polymorphism in primary adult-onset dystonia: a case-control study 
      and meta-analysis.
PG  - 1083-6
LID - 10.1002/mds.25938 [doi]
AB  - BACKGROUND: A polymorphism in brain-derived neurotrophic factor (BDNF) (Val66Met) 
      has been reported as a risk factor in primary dystonia. However, overall the 
      results have been inconclusive. Our aim was to clarify the association of 
      Val66Met with primary dystonia, and with the most prevalent clinical subtypes, 
      cervical dystonia and blepharospasm. METHODS: We conducted a Spanish multicenter 
      case-control study (including 680 primary dystonia patients and 788 healthy 
      controls) and performed a meta-analysis integrating our study and six previously 
      published studies (including a total of 1,936 primary dystonia patients and 2,519 
      healthy controls). RESULTS: We found no allelic or genotypic association with 
      primary dystonia, cervical dystonia, or blepharospasm risks, for the allele A 
      (Met) from a BDNF Val66Met polymorphism in our case-control study. This was 
      confirmed by results from our meta-analysis in white and mixed ethnic populations 
      in any genetic model. CONCLUSION: We did not find any evidence supporting the 
      association of the BDNF Val66Met polymorphism with primary dystonia.
CI  - (c) 2014 International Parkinson and Movement Disorder Society.
FAU - Gomez-Garre, Pilar
AU  - Gomez-Garre P
AD  - Unidad de Trastornos del Movimiento, Servicio de Neurologia y Neurofisiologia 
      Clinica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del 
      Rocio/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigacion 
      Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain.
FAU - Huertas-Fernandez, Ismael
AU  - Huertas-Fernandez I
FAU - Caceres-Redondo, Maria Teresa
AU  - Caceres-Redondo MT
FAU - Alonso-Canovas, Araceli
AU  - Alonso-Canovas A
FAU - Bernal-Bernal, Inmaculada
AU  - Bernal-Bernal I
FAU - Blanco-Ollero, Alberto
AU  - Blanco-Ollero A
FAU - Bonilla-Toribio, Marta
AU  - Bonilla-Toribio M
FAU - Burguera, Juan Andres
AU  - Burguera JA
FAU - Carballo, Manuel
AU  - Carballo M
FAU - Carrillo, Fatima
AU  - Carrillo F
FAU - Catalan-Alonso, Maria Jose
AU  - Catalan-Alonso MJ
FAU - Escamilla-Sevilla, Francisco
AU  - Escamilla-Sevilla F
FAU - Espinosa-Rosso, Raul
AU  - Espinosa-Rosso R
FAU - Fernandez-Moreno, Maria Carmen
AU  - Fernandez-Moreno MC
FAU - Garcia-Caldentey, Juan
AU  - Garcia-Caldentey J
FAU - Garcia-Moreno, Jose Manuel
AU  - Garcia-Moreno JM
FAU - Garcia-Ruiz, Pedro Jose
AU  - Garcia-Ruiz PJ
FAU - Giacometti-Silveira, Sandra
AU  - Giacometti-Silveira S
FAU - Gutierrez-Garcia, Javier
AU  - Gutierrez-Garcia J
FAU - Jesus, Silvia
AU  - Jesus S
FAU - Lopez-Valdes, Eva
AU  - Lopez-Valdes E
FAU - Martinez-Castrillo, Juan Carlos
AU  - Martinez-Castrillo JC
FAU - Martinez-Torres, Irene
AU  - Martinez-Torres I
FAU - Medialdea-Natera, Maria Pilar
AU  - Medialdea-Natera MP
FAU - Mendez-Lucena, Carolina
AU  - Mendez-Lucena C
FAU - Minguez-Castellanos, Adolfo
AU  - Minguez-Castellanos A
FAU - Moya, Miguel
AU  - Moya M
FAU - Ochoa-Sepulveda, Juan Jose
AU  - Ochoa-Sepulveda JJ
FAU - Ojea, Tomas
AU  - Ojea T
FAU - Rodriguez, Nuria
AU  - Rodriguez N
FAU - Sillero-Sanchez, Miriam
AU  - Sillero-Sanchez M
FAU - Vargas-Gonzalez, Laura
AU  - Vargas-Gonzalez L
FAU - Mir, Pablo
AU  - Mir P
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140612
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Dystonic Disorders/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Valine/genetics
OTO - NOTNLM
OT  - BDNF
OT  - Primary dystonia
OT  - Val66Met
OT  - association study
OT  - meta-analysis
EDAT- 2014/06/14 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/06/14 06:00
PHST- 2014/01/31 00:00 [received]
PHST- 2014/03/27 00:00 [revised]
PHST- 2014/05/08 00:00 [accepted]
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1002/mds.25938 [doi]
PST - ppublish
SO  - Mov Disord. 2014 Jul;29(8):1083-6. doi: 10.1002/mds.25938. Epub 2014 Jun 12.