PMID- 24926235
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20211021
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 8
DP  - 2014
TI  - Neurotrophins and spinal circuit function.
PG  - 59
LID - 10.3389/fncir.2014.00059 [doi]
LID - 59
AB  - Work early in the last century emphasized the stereotyped activity of spinal 
      circuits based on studies of reflexes. However, the last several decades have 
      focused on the plasticity of these spinal circuits. These considerations began 
      with studies of the effects of monoamines on descending and reflex circuits. In 
      recent years new classes of compounds called growth factors that are found in 
      peripheral nerves and the spinal cord have been shown to affect circuit behavior 
      in the spinal cord. In this review we will focus on the effects of neurotrophins, 
      particularly nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) 
      and neurotrophin-3 (NT-3), on spinal circuits. We also discuss evidence that 
      these molecules can modify functions including nociceptive behavior, motor 
      reflexes and stepping behavior. Since these substances and their receptors are 
      normally present in the spinal cord, they could potentially be useful in 
      improving function in disease states and after injury. Here we review recent 
      findings relevant to these translational issues.
FAU - Boyce, Vanessa S
AU  - Boyce VS
AD  - Department of Neurobiology and Behavior, Stony Brook University Stony Brook, NY, 
      USA.
FAU - Mendell, Lorne M
AU  - Mendell LM
AD  - Department of Neurobiology and Behavior, Stony Brook University Stony Brook, NY, 
      USA.
LA  - eng
GR  - R01 NS016996/NS/NINDS NIH HHS/United States
GR  - 5 R01NS16996/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140605
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Motor Activity/*physiology
MH  - Nerve Growth Factors/*metabolism
MH  - Nerve Net/*metabolism
MH  - Spinal Cord/*metabolism
MH  - Spinal Cord Injuries/metabolism
PMC - PMC4046666
OTO - NOTNLM
OT  - c-Fos
OT  - locomotion
OT  - motor neuron
OT  - neurotrophin
OT  - nociceptor
OT  - pain
OT  - spinal cord injury
OT  - stretch reflex
EDAT- 2014/06/14 06:00
MHDA- 2014/09/25 06:00
PMCR- 2014/01/01
CRDT- 2014/06/14 06:00
PHST- 2014/03/08 00:00 [received]
PHST- 2014/05/19 00:00 [accepted]
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2014.00059 [doi]
PST - epublish
SO  - Front Neural Circuits. 2014 Jun 5;8:59. doi: 10.3389/fncir.2014.00059. 
      eCollection 2014.