PMID- 24926952
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20211021
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 99
IP  - 9
DP  - 2014 Sep
TI  - Association of adenovirus 36 infection with adiposity and inflammatory-related 
      markers in children.
PG  - 3240-6
LID - 10.1210/jc.2014-1780 [doi]
AB  - CONTEXT: Although animal studies suggest that adenovirus 36 (Ad36) infection is 
      linked to obesity and systemic inflammation, human data are scant and equivocal. 
      OBJECTIVE: Associations of Ad36 infection with total body adiposity and 
      inflammatory-related markers were determined in 291 children aged 9-13 years (50% 
      female, 49% black). DESIGN: Fasting blood samples were measured for presence of 
      Ad36-specific antibodies and TNF-alpha, IL-6, vascular endothelial growth factor 
      (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free 
      soft tissue mass were measured by dual-energy X-ray absorptiometry. RESULTS: The 
      overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher 
      percentage of Ad36(+) children in the highest tertiles of TNF-alpha and IL-6 compared 
      with their respective middle and lowest tertiles (both P < .03). There was also a 
      trend toward a higher prevalence of Ad36(+) children in the highest tertile of 
      VEGF compared with tertiles 1 and 2 (P = .05). Multinomial logistic regression, 
      adjusting for age, race, sex, and fat-free soft tissue mass, revealed that 
      compared with children with the lowest TNF-alpha, IL-6, and VEGF levels (tertile 1), 
      the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 
      1.2-4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0-3.3), respectively, for those 
      in the highest TNF-alpha, IL-6, and VEGF levels (tertile 3). No association was 
      observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05). 
      CONCLUSIONS: In children, our data suggest that Ad36(+) may be associated with 
      biomarkers implicated in inflammation but not with greater levels of fat mass.
FAU - Berger, P K
AU  - Berger PK
AD  - Department of Foods and Nutrition (P.K.B., E.M.L., D.B.H., R.D.L.), The 
      University of Georgia, Athens, Georgia 30602; Department of Pediatrics (N.K.P.), 
      Georgia Regents University, Augusta, Georgia 30912; Department of Physical 
      Therapy (S.J.W.), Indiana University School of Health and Rehabilitation 
      Sciences, and Department of Medicine (K.M.H.G., M.P.), Indiana University School 
      of Medicine, Indianapolis, Indiana 46202; Departments of Nutrition Science 
      (K.M.H.G., L.D.M., C.M.W.) and Statistics (G.P.M.), Purdue University, West 
      Lafayette, Indiana 47907; and Department of Infectious Diseases (R.A.T.), The 
      University of Georgia, Athens, Georgia 30602.
FAU - Pollock, N K
AU  - Pollock NK
FAU - Laing, E M
AU  - Laing EM
FAU - Warden, S J
AU  - Warden SJ
FAU - Hill Gallant, K M
AU  - Hill Gallant KM
FAU - Hausman, D B
AU  - Hausman DB
FAU - Tripp, R A
AU  - Tripp RA
FAU - McCabe, L D
AU  - McCabe LD
FAU - McCabe, G P
AU  - McCabe GP
FAU - Weaver, C M
AU  - Weaver CM
FAU - Peacock, M
AU  - Peacock M
FAU - Lewis, R D
AU  - Lewis RD
LA  - eng
GR  - R01HD057126/HD/NICHD NIH HHS/United States
GR  - R01 HL087923/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001108/TR/NCATS NIH HHS/United States
GR  - R01 HD057126/HD/NICHD NIH HHS/United States
GR  - L40 HL110299/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140613
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Antibodies, Viral)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adenoviridae/*immunology
MH  - Adenovirus Infections, Human/*epidemiology/*immunology
MH  - Adiposity/*immunology
MH  - Adolescent
MH  - Antibodies, Viral/blood
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Inflammation/*epidemiology/*immunology
MH  - Interleukin-6/blood
MH  - Male
MH  - Odds Ratio
MH  - Prevalence
MH  - Seroepidemiologic Studies
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Vascular Endothelial Growth Factor A/blood
PMC - PMC4154093
EDAT- 2014/06/14 06:00
MHDA- 2015/01/13 06:00
PMCR- 2015/09/01
CRDT- 2014/06/14 06:00
PHST- 2014/06/14 06:00 [entrez]
PHST- 2014/06/14 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 14-1780 [pii]
AID - 10.1210/jc.2014-1780 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2014 Sep;99(9):3240-6. doi: 10.1210/jc.2014-1780. Epub 
      2014 Jun 13.