PMID- 24927914
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20151119
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 35
IP  - 8
DP  - 2014 Aug
TI  - Inflammation-induced fetal growth restriction in rats is associated with altered 
      placental morphometrics.
PG  - 575-81
LID - S0143-4004(14)00194-5 [pii]
LID - 10.1016/j.placenta.2014.05.002 [doi]
AB  - INTRODUCTION: Evidence links alterations in placental shape and size to fetal 
      growth restriction (FGR). Here we determined whether alterations in placental 
      morphometrics are linked to FGR induced by abnormal maternal inflammation. 
      METHODS: We used an inflammation-induced model of FGR in which pregnant rats 
      receive lipopolysaccharide (LPS) on gestational days (GD) 13.5-16.5. Fetal 
      weights were matched to various parameters of placental morphometrics including 
      weight, area, minor and major axes lengths and thickness. RESULTS: Compared with 
      saline administration, LPS administration was associated with altered placental 
      morphometrics, including reduced placental weight, decreased placental area and a 
      trend towards reduced placental thickness. When data were dichotomized as FGR or 
      normal-sized fetuses within treatment groups, a significant increase in the 
      placental-weight-to-fetal-weight ratio and placental thickness was observed only 
      in the saline-associated FGR subgroup. Multivariable linear regression revealed 
      that the lengths of the major and minor placental axes were predictors of fetal 
      weight, regardless of treatment modality. Subgroup regression analysis by 
      treatment revealed that the lengths of the major and minor placental axes were 
      predictors of fetal weight in the saline-treatment group while only the minor 
      placental axis was a predictor of fetal weight in the LPS cohort. Finally, 
      placental area and the length of the minor placental axis were correlated with 
      implantation site location only in the saline-treatment group. 
      DISCUSSION/CONCLUSION: These findings indicate that inflammation-induced FGR is 
      associated with alterations in placental morphometrics. Our data reveal that the 
      mechanisms leading to inflammation-induced FGR may be different from the 
      mechanisms leading to idiopathic FGR.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Cotechini, T
AU  - Cotechini T
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario K7L 3N6, Canada. Electronic address: 4tc16@queensu.ca.
FAU - Hopman, W J
AU  - Hopman WJ
AD  - Clinical Research Centre, Kingston General Hospital, Kingston, Ontario, Canada; 
      Department of Public Health Sciences, Queen's University, Kingston, Ontario, 
      Canada.
FAU - Graham, C H
AU  - Graham CH
AD  - Department of Biomedical and Molecular Sciences, Queen's University, Kingston, 
      Ontario K7L 3N6, Canada. Electronic address: grahamc@queensu.ca.
LA  - eng
GR  - MOP 119496/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140520
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (Lipopolysaccharides)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Embryo Implantation
MH  - Female
MH  - Fetal Development
MH  - Fetal Growth Retardation/*immunology/pathology
MH  - Fetal Weight
MH  - Linear Models
MH  - Lipopolysaccharides
MH  - Placenta/pathology
MH  - *Placentation
MH  - Pregnancy
MH  - Rats, Wistar
MH  - Sodium Chloride
OTO - NOTNLM
OT  - Fetal growth restriction
OT  - Inflammation
OT  - Minor axis
OT  - Placenta
OT  - Placental morphometry
OT  - Pre-eclampsia
EDAT- 2014/06/15 06:00
MHDA- 2015/04/14 06:00
CRDT- 2014/06/15 06:00
PHST- 2014/01/24 00:00 [received]
PHST- 2014/03/25 00:00 [revised]
PHST- 2014/05/07 00:00 [accepted]
PHST- 2014/06/15 06:00 [entrez]
PHST- 2014/06/15 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - S0143-4004(14)00194-5 [pii]
AID - 10.1016/j.placenta.2014.05.002 [doi]
PST - ppublish
SO  - Placenta. 2014 Aug;35(8):575-81. doi: 10.1016/j.placenta.2014.05.002. Epub 2014 
      May 20.