PMID- 24927950
OWN - NLM
STAT- MEDLINE
DCOM- 20151001
LR  - 20220408
IS  - 0975-0711 (Electronic)
IS  - 0254-8860 (Linking)
VI  - 33
IP  - 5
DP  - 2014 Sep
TI  - Acid-fast bacilli culture positivity and drug resistance in abdominal 
      tuberculosis in Mumbai, India.
PG  - 414-9
LID - 10.1007/s12664-014-0467-x [doi]
AB  - BACKGROUND AND AIM: Culture positivity for Mycobacterium tuberculosis complex 
      (MTB) in abdominal tuberculosis (TB) using Lowenstein Jensen medium and Bactec 
      system varies from 25 % to 36 %. Data on the prevalence of drug resistance in 
      primary abdominal TB is scant. Our aim was to study the acid-fast bacilli (AFB) 
      culture positivity rate in primary abdominal TB using Bactec Mycobacterial Growth 
      Indicator Tubes (MGIT) system and the prevalence of drug resistance in these 
      patients. METHOD: Records of patients with abdominal TB (diagnosed on clinical 
      features, endoscopy, histology, microbiology) seen during the period 2008 to 2013 
      were retrieved from the Gastroenterology and Microbiology departments. Patients 
      with extra-abdominal TB (five pulmonary, two nodal), adnexal (one), and HIV (one) 
      were excluded from analysis. RESULTS: Of 61 patients, 31 (50.8 %) had a positive 
      AFB culture. In the 30 culture-negative patients, histology showed non-caseating 
      granulomas in 25 patients. Drug sensitivity pattern was analyzed in 18 patients; 
      resistance was detected in eight (14.3 % of all patients and 44.4 % of patients 
      in whom drug sensitivity was done) including three (5.4 % of all subjects and 
      16.6 % in whom drug sensitivity was available) who were multidrug-resistant. 
      CONCLUSIONS: The rate of AFB culture positivity in primary abdominal TB was 50.8 
      % using Bactec MGIT. Likelihood of drug resistance was seen in 14.3 %, of whom 
      5.4 % were multidrug-resistant.
FAU - Samant, Hrishikesh
AU  - Samant H
AD  - Division of Gastroenterology, P D Hinduja National Hospital and Medical Research 
      Centre, Swatantrya Veer Savarkar Marg, Mahim West, Mumbai, 400 016, India.
FAU - Desai, Devendra
AU  - Desai D
FAU - Abraham, Philip
AU  - Abraham P
FAU - Joshi, Anand
AU  - Joshi A
FAU - Gupta, Tarun
AU  - Gupta T
FAU - Rodrigues, Camilla
AU  - Rodrigues C
FAU - George, Siji
AU  - George S
LA  - eng
PT  - Journal Article
DEP - 20140615
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
RN  - 0 (Antitubercular Agents)
SB  - IM
CIN - Indian J Gastroenterol. 2015 Mar;34(2):184. PMID: 25274295
CIN - Indian J Gastroenterol. 2015 Mar;34(2):185. PMID: 25576387
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antitubercular Agents/*pharmacology
MH  - Drug Resistance, Bacterial
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Microbial Sensitivity Tests/methods
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/*drug effects/*isolation & purification
MH  - Prevalence
MH  - Retrospective Studies
MH  - Tuberculosis, Gastrointestinal/*epidemiology/*microbiology
MH  - Young Adult
EDAT- 2014/06/15 06:00
MHDA- 2015/10/02 06:00
CRDT- 2014/06/15 06:00
PHST- 2014/01/10 00:00 [received]
PHST- 2014/05/07 00:00 [accepted]
PHST- 2014/06/15 06:00 [entrez]
PHST- 2014/06/15 06:00 [pubmed]
PHST- 2015/10/02 06:00 [medline]
AID - 10.1007/s12664-014-0467-x [doi]
PST - ppublish
SO  - Indian J Gastroenterol. 2014 Sep;33(5):414-9. doi: 10.1007/s12664-014-0467-x. 
      Epub 2014 Jun 15.