PMID- 24930517
OWN - NLM
STAT- MEDLINE
DCOM- 20150422
LR  - 20220316
IS  - 1899-1505 (Electronic)
IS  - 0867-5910 (Linking)
VI  - 65
IP  - 3
DP  - 2014 Jun
TI  - Moderate-intensity interval training increases serum brain-derived neurotrophic 
      factor level and decreases inflammation in Parkinson's disease patients.
PG  - 441-8
AB  - It has been demonstrated that physical training increases serum brain-derived 
      neurotrophic factor (BDNF) in healthy people. The aim of this study was to 
      establish the effect of physical training on the basal serum level of the BDNF in 
      the Parkinson's disease patients (PD patients) in relation to their health 
      status. Twelve PD patients (mean +/- S.E.M: age 70 +/- 3 years; body mass 70 +/- 2 kg; 
      height 163 +/- 3 cm) performed a moderate-intensity interval training (three 1-hour 
      training sessions weekly), lasting 8 weeks. Basal serum BDNF in the PD patients 
      before training amounted to 10,977 +/- 756 pg x mL(-1) and after 8 weeks of 
      training it has increased to 14,206 +/- 1256 pg x mL(-1) (i.e. by 34%, P=0.03). 
      This was accompanied by an attenuation of total Unified Parkinson's Disease 
      Rating Scale (UPDRS) (P=0.01). The training resulted also in a decrease of basal 
      serum soluble vascular cell adhesion molecule 1 (sVCAM-1) (P=0.001) and serum 
      tumor necrosis factor-alpha (TNF-alpha) (P=0.03) levels. We have concluded that the 
      improvement of health status of the Parkinson's disease patients after training 
      could be related to the increase of serum BDNF level caused by the attenuated 
      inflammation in those patients.
FAU - Zoladz, J A
AU  - Zoladz JA
AD  - Department of Muscle Physiology, Chair of Physiology and Biochemistry, Faculty of 
      Rehabilitation, University School of Physical Education, Cracow, Poland. 
      jerzy.zoladz@awf.krakow.pl.
FAU - Majerczak, J
AU  - Majerczak J
FAU - Zeligowska, E
AU  - Zeligowska E
FAU - Mencel, J
AU  - Mencel J
FAU - Jaskolski, A
AU  - Jaskolski A
FAU - Jaskolska, A
AU  - Jaskolska A
FAU - Marusiak, J
AU  - Marusiak J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Inflammation/metabolism/*pathology
MH  - Male
MH  - Oxidative Stress
MH  - Parkinson Disease/*blood/metabolism/*pathology
EDAT- 2014/06/17 06:00
MHDA- 2015/04/23 06:00
CRDT- 2014/06/17 06:00
PHST- 2014/01/14 00:00 [received]
PHST- 2014/03/06 00:00 [accepted]
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2015/04/23 06:00 [medline]
PST - ppublish
SO  - J Physiol Pharmacol. 2014 Jun;65(3):441-8.