PMID- 24931064
OWN - NLM
STAT- MEDLINE
DCOM- 20150729
LR  - 20141202
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 23
IP  - 11
DP  - 2014 Nov
TI  - Use of the CRUSADE bleeding risk score in the prediction of major bleeding for 
      patients with acute coronary syndrome receiving enoxaparin in Thailand.
PG  - 1051-8
LID - S1443-9506(14)00455-7 [pii]
LID - 10.1016/j.hlc.2014.05.002 [doi]
AB  - BACKGROUND: CRUSADE risk score stands out as a simple-to-use bleeding risk model. 
      However, its use is still doubtful for Thai population. The aim of this study was 
      to assess the prognostic value of CRUSADE in predicting risk of major bleeding 
      among Thai patients with acute coronary syndrome (ACS) receiving enoxaparin. 
      METHODS: A retrospective cohort study was performed using patients with ACS who 
      were hospitalised at a university hospital in Bangkok between 2006 and 2009 and 
      had received enoxaparin. The CRUSADE risk score was calculated. The model 
      validation was tested by using C statistic and Hosmer-Lemeshow goodness-of-fit. 
      RESULTS: The overall incidence of major bleeding was 18.3%. Median CRUSADE score 
      for entire study population, unstable angina (UA), non-ST elevation myocardial 
      infarction (NSTEMI), and ST elevation myocardial infarction (STEMI) were 49, 47, 
      53, and 39, respectively. Hosmer-Lemeshow goodness of fit revealed no statistical 
      significance in all groups. The CRUSADE model demonstrated a satisfactory 
      discriminatory capacity for the entire study population (C = 0.688), UA (C = 
      0.591), NSTEMI (C = 0.693), and STEMI groups (C = 0.736). CONCLUSIONS: Across the 
      ACS spectrum, CRUSADE risk score was able to estimate in-hospital major bleeding 
      of Thai patients with ACS who received treatment with enoxaparin. The application 
      of these results in Thailand may be helpful in the identification of patients at 
      high bleeding risk and also may lead to implementation of appropriate prevention.
CI  - Copyright (c) 2014 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      Published by Elsevier B.V. All rights reserved.
FAU - Jinatongthai, Peerawat
AU  - Jinatongthai P
AD  - Pharmacy Practice Division, Faculty of Pharmaceutical Sciences, Ubon Ratchathani 
      University, Thailand.
FAU - Khaisombut, Narinee
AU  - Khaisombut N
AD  - Phayathai 3 Hospital, Bangkok, Thailand.
FAU - Likittanasombat, Khanchit
AU  - Likittanasombat K
AD  - Divisions of Cardiology, Department of Medicine, Faculty of Medicine, Ramathibodi 
      Hospital, Mahidol University, Thailand.
FAU - Chaiyakunapruk, Nathorn
AU  - Chaiyakunapruk N
AD  - School of Pharmacy, Monash University Malaysia, Selangor, Malaysia; Center of 
      Pharmaceutical Outcomes Research (CPOR), Department of Pharmacy Practice, Faculty 
      of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand; School of 
      Pharmacy, University of Wisconsin, Madison, USA; School of Population Health, 
      University of Queensland, Brisbane, Australia.
FAU - Watcharathanakij, Sawaeng
AU  - Watcharathanakij S
AD  - Pharmacy Practice Division, Faculty of Pharmaceutical Sciences, Ubon Ratchathani 
      University, Thailand.
FAU - Nathisuwan, Surakit
AU  - Nathisuwan S
AD  - Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Thailand. 
      Electronic address: pysnt@mahidol.ac.th.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20140524
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
RN  - 0 (Enoxaparin)
RN  - 0 (Fibrinolytic Agents)
SB  - IM
MH  - *Acute Coronary Syndrome/drug therapy/epidemiology
MH  - Enoxaparin/administration & dosage/*adverse effects
MH  - Female
MH  - Fibrinolytic Agents/administration & dosage/*adverse effects
MH  - *Hemorrhage/chemically induced/diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Thailand
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - CRUSADE risk score
OT  - Enoxaparin
OT  - Major bleeding
OT  - Thailand
EDAT- 2014/06/17 06:00
MHDA- 2015/07/30 06:00
CRDT- 2014/06/17 06:00
PHST- 2013/10/08 00:00 [received]
PHST- 2014/04/27 00:00 [revised]
PHST- 2014/05/04 00:00 [accepted]
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2015/07/30 06:00 [medline]
AID - S1443-9506(14)00455-7 [pii]
AID - 10.1016/j.hlc.2014.05.002 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2014 Nov;23(11):1051-8. doi: 10.1016/j.hlc.2014.05.002. Epub 
      2014 May 24.