PMID- 24931645
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20211021
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 76
IP  - 10
DP  - 2014 Oct
TI  - Preliminary study characterizing the use of sitagliptin for glycemic control in 
      healthy Beagle dogs with normal gluco-homeostasis.
PG  - 1383-7
AB  - Sitagliptin is a dipeptidyl peptidase-4 inhibitor aimed at treating Type 2 
      diabetes mellitus (T2DM) and T1DM, by increasing blood levels of Glucagon-like 
      peptide 1 (GLP-1) and insulin. The objective of this preliminary study is to 
      characterize Sitagliptin's ability for glycemic control, in healthy dogs under an 
      oral glucose tolerance test (OGTT) environment. Overall, Sitagliptin did not 
      result in any significant changes to temporal glucose and insulin concentrations. 
      However, a ~55% increase in median total GLP-1 AUC0-120 min was observed, as 
      compared to baseline control in healthy dogs (n=5), thus indicating a similar 
      mode of action of Sitagliptin between healthy dogs and humans. Future studies to 
      validate the use of Sitagliptin with dogs suffering from insulin independent 
      diabetes are warranted.
FAU - Oda, Hitomi
AU  - Oda H
AD  - School of Veterinary Nursing and Technology, Faculty of Veterinary Science, 
      Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 
      180-8602, Japan.
FAU - Mori, Akihiro
AU  - Mori A
FAU - Lee, Peter
AU  - Lee P
FAU - Saeki, Kaori
AU  - Saeki K
FAU - Arai, Toshiro
AU  - Arai T
FAU - Sako, Toshinori
AU  - Sako T
LA  - eng
PT  - Journal Article
DEP - 20140616
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Pyrazines)
RN  - 0 (Triazoles)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - TS63EW8X6F (Sitagliptin Phosphate)
SB  - IM
MH  - Animals
MH  - Area Under Curve
MH  - Blood Glucose/*drug effects
MH  - Dogs/*blood
MH  - Gene Expression Regulation
MH  - Glucagon-Like Peptide 1/blood/genetics/metabolism
MH  - Homeostasis/*drug effects
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin/blood/metabolism
MH  - Pyrazines/*pharmacology
MH  - Sitagliptin Phosphate
MH  - Triazoles/*pharmacology
PMC - PMC4221172
EDAT- 2014/06/17 06:00
MHDA- 2015/07/03 06:00
PMCR- 2014/10/01
CRDT- 2014/06/17 06:00
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jvms/13-0590 [pii]
AID - 13-0590 [pii]
AID - 10.1292/jvms.13-0590 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2014 Oct;76(10):1383-7. doi: 10.1292/jvms.13-0590. Epub 2014 Jun 
      16.