PMID- 24931702 OWN - NLM STAT- MEDLINE DCOM- 20141113 LR - 20151119 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 105 IP - 2 DP - 2014 Aug TI - Relationships between adipokines, biomarkers of endothelial function and inflammation and risk of type 2 diabetes. PG - 231-8 LID - S0168-8227(14)00215-0 [pii] LID - 10.1016/j.diabres.2014.05.001 [doi] AB - AIMS: Identification of novel biomarkers of diabetes risk help to understand mechanisms of pathogenesis and improve risk prediction. Our objectives were to examine the relationships between adipokines, biomarkers of inflammation and endothelial function and development of type 2 diabetes; and to assess the relevance of including these biomarkers in type 2 diabetes prediction risk models. METHODS: 1345 subjects from the SU.VI.MAX study, who were free of diabetes at baseline and who completed 13 years of follow-up were included in the present analyses. Odds ratios (OR) with 95% confidence intervals (95% CI) of incident type 2 diabetes associated with a 1-SD increase in adiponectin, leptin, C-reactive protein (CRP), soluble intracellular adhesion modecule-1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), E-selectin and monocyte chemoattractant protein-1 (MCP-1) were estimated. Predicitive performances of models including biomarkers were assessed with area under the receiver operating curves (AUC) and integrated discrimination improvement (IDI) statistics. RESULTS: 82 subjects developed type 2 diabetes during follow-up. The risk of developing type 2 diabetes increased with increasing concentrations of leptin (2.04 (1.28;3.26)), sICAM-1 (1.39 (1.08;1.78)) and sVCAM-1 (1.29 (1.01;1.64)). Type 2 diabetes associations with leptin remained significant after adjusting for a combination of biomarkers. Models adjusted for novel biomarkers had improved performance compared to models adjusted for classical risk factors as assessed by IDI, but not by AUC. CONCLUSIONS: Adipokines, biomarkers of inflammation and endothelial function were significantly associated to onset of type 2 diabetes. However their inclusion in predictive scores is not supported by the present study. CI - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved. FAU - Julia, C AU - Julia C AD - Equipe de Recherche en Epidemiologie Nutritionnelle (EREN), Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite (CRESS) U1153 Inserm; U1125, Inra; Cnam; Universite Paris 13, Universite Paris 7, Uniersite Paris 5, Bobigny, France; Departement de Sante Publique, Hopital Avicenne (AP-HP); Universite Paris 13, Bobigny, France. Electronic address: c.julia@uren.smbh.univ-paris13.fr. FAU - Czernichow, S AU - Czernichow S AD - INSERM, U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France; Universite Versailles St-Quentin, Boulogne-Billancourt, France; APHP, Hopital Ambroise Pare, Service de Nutrition, Boulogne-Billancourt, France. FAU - Charnaux, N AU - Charnaux N AD - Department of Biochemistry, Jean-Verdier Hospital (AP-HP), Bondy, France. FAU - Ahluwalia, N AU - Ahluwalia N AD - Equipe de Recherche en Epidemiologie Nutritionnelle (EREN), Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite (CRESS) U1153 Inserm; U1125, Inra; Cnam; Universite Paris 13, Universite Paris 7, Uniersite Paris 5, Bobigny, France. FAU - Andreeva, V AU - Andreeva V AD - Equipe de Recherche en Epidemiologie Nutritionnelle (EREN), Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite (CRESS) U1153 Inserm; U1125, Inra; Cnam; Universite Paris 13, Universite Paris 7, Uniersite Paris 5, Bobigny, France. FAU - Touvier, M AU - Touvier M AD - Equipe de Recherche en Epidemiologie Nutritionnelle (EREN), Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite (CRESS) U1153 Inserm; U1125, Inra; Cnam; Universite Paris 13, Universite Paris 7, Uniersite Paris 5, Bobigny, France. FAU - Galan, P AU - Galan P AD - Equipe de Recherche en Epidemiologie Nutritionnelle (EREN), Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite (CRESS) U1153 Inserm; U1125, Inra; Cnam; Universite Paris 13, Universite Paris 7, Uniersite Paris 5, Bobigny, France. FAU - Fezeu, L AU - Fezeu L AD - Equipe de Recherche en Epidemiologie Nutritionnelle (EREN), Centre de Recherche en Epidemiologies et Biostatistiques Sorbonne Paris Cite (CRESS) U1153 Inserm; U1125, Inra; Cnam; Universite Paris 13, Universite Paris 7, Uniersite Paris 5, Bobigny, France. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140517 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 RN - 0 (Adipokines) RN - 0 (Adiponectin) RN - 0 (Biomarkers) RN - 0 (Chemokine CCL2) RN - 0 (E-Selectin) RN - 0 (Leptin) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adipokines/*metabolism MH - Adiponectin/metabolism MH - Adult MH - Biomarkers/*metabolism MH - C-Reactive Protein/metabolism MH - Case-Control Studies MH - Chemokine CCL2/metabolism MH - Diabetes Mellitus, Type 2/*metabolism/pathology MH - Double-Blind Method MH - E-Selectin/metabolism MH - Endothelium, Vascular/*metabolism MH - Female MH - Follow-Up Studies MH - Humans MH - Inflammation/*metabolism/pathology MH - Leptin/metabolism MH - Male MH - Middle Aged MH - Odds Ratio MH - Risk Factors OTO - NOTNLM OT - Adipokines OT - Diabetes mellitus, type 2 OT - E-selectin OT - Inflammation OT - Intercellular cell adhesion molecule-1 OT - Vascular cell adhesion molecule-1 EDAT- 2014/06/17 06:00 MHDA- 2014/11/14 06:00 CRDT- 2014/06/17 06:00 PHST- 2013/01/11 00:00 [received] PHST- 2014/04/14 00:00 [revised] PHST- 2014/05/12 00:00 [accepted] PHST- 2014/06/17 06:00 [entrez] PHST- 2014/06/17 06:00 [pubmed] PHST- 2014/11/14 06:00 [medline] AID - S0168-8227(14)00215-0 [pii] AID - 10.1016/j.diabres.2014.05.001 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2014 Aug;105(2):231-8. doi: 10.1016/j.diabres.2014.05.001. Epub 2014 May 17.