PMID- 24931816
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20211203
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Linking)
VI  - 38
IP  - 7
DP  - 2014 Jul
TI  - Protective effect of Flos puerariae extract following acute alcohol intoxication 
      in mice.
PG  - 1839-46
LID - 10.1111/acer.12437 [doi]
AB  - BACKGROUND: The effect of Flos Puerariae extract (FPE) on alcohol metabolism, 
      hepatic injury, and memory impairment was assessed following acute ethanol (EtOH) 
      intoxication in mice. METHODS: The model of acute EtOH intoxication was 
      established by intragastric administration with 8 g/kg EtOH in mice. FPE was 
      orally administrated (gavage) once a day for 7 consecutive days. Mice were 
      randomly divided into 4 groups: control group, model group, and FPE groups (100, 
      200 mg/kg). Alcohol tolerance and intoxication time, blood alcohol concentration, 
      the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) 
      in liver, aspartate amino transferase (AST) and alanine amino transferase (ALT) 
      in serum, superoxide dismutase (SOD), glutathione peroxidase (GSH-px), catalase 
      and the formation of malondialdehyde (MDA) in both liver and brain, as well as 
      memory ability were determined after acute alcohol exposure. RESULTS: Compared 
      with model group, pretreatment with FPE significantly prolonged alcohol tolerance 
      time and shortened intoxication time, which is accompanied by decreased blood 
      alcohol concentration and elevated activities of ADH and ALDH in liver. Moreover, 
      the index of hepatic injury, ALT, and AST activities in serum was markedly 
      decreased by pretreatment with FPE. Additionally, decreased MDA level, enhanced 
      GSH-px and catalase activities in liver, as well as enhanced SOD and catalase 
      activities in brain were found in FPE pretreated mice after acute exposure to 
      EtOH. Furthermore, FPE pretreated mice showed markedly relieved memory disruption 
      following acute EtOH intoxication. CONCLUSIONS: This study suggests that FPE 
      pretreatment could enhance alcohol metabolism, prevent hepatic injury, and 
      relieve memory impairment after acute alcohol intoxication and that this effect 
      is likely related to its modulation on the alcohol metabolizing and antioxidant 
      enzymes.
CI  - Copyright (c) 2014 by the Research Society on Alcoholism.
FAU - Chen, Xiao
AU  - Chen X
AD  - Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic 
      Disorders, Hubei University of Science and Technology, Xianning, China.
FAU - Cai, Fei
AU  - Cai F
FAU - Guo, Shuang
AU  - Guo S
FAU - Ding, Fang
AU  - Ding F
FAU - He, Yi
AU  - He Y
FAU - Wu, Jiliang
AU  - Wu J
FAU - Liu, Chao
AU  - Liu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140613
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Puerariae Flos extract)
RN  - 3K9958V90M (Ethanol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.1.1.1 (Alcohol Dehydrogenase)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Alcohol Dehydrogenase/metabolism
MH  - Alcoholic Intoxication/blood/*complications/*drug therapy/enzymology/psychology
MH  - Aldehyde Dehydrogenase/metabolism
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Brain/drug effects/enzymology/metabolism
MH  - Catalase/metabolism
MH  - Chemical and Drug Induced Liver Injury/complications/drug 
      therapy/enzymology/*prevention & control
MH  - Drug Tolerance
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Ethanol/blood/pharmacokinetics/toxicity
MH  - Glutathione Peroxidase/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Memory Disorders/chemically induced/*complications/*drug therapy/enzymology
MH  - Mice
MH  - Pueraria
MH  - Superoxide Dismutase/metabolism
MH  - Time Factors
OTO - NOTNLM
OT  - Alcohol Dehydrogenase
OT  - Alcoholism
OT  - Aldehyde Dehydrogenase
OT  - Antioxidant
OT  - Flos Puerariae
EDAT- 2014/06/17 06:00
MHDA- 2015/04/15 06:00
CRDT- 2014/06/17 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/03/26 00:00 [accepted]
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - 10.1111/acer.12437 [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2014 Jul;38(7):1839-46. doi: 10.1111/acer.12437. Epub 2014 
      Jun 13.