PMID- 24932104
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140616
LR  - 20211021
IS  - 1178-6388 (Print)
IS  - 1178-6388 (Electronic)
IS  - 1178-6388 (Linking)
VI  - 7
DP  - 2014
TI  - Nutritional Effect of Oral Supplement Enriched in omega-3 Fatty Acids, Arginine, RNA 
      on Immune Response and Leukocyte-platelet Aggregate Formation in Patients 
      Undergoing Cardiac Surgery.
PG  - 39-46
LID - 10.4137/NMI.S13810 [doi]
AB  - The aim of the present study was to investigate the influence of a supplement 
      enriched in omega-3 fatty acids on immune responses and platelet-leukocyte complex 
      formation in patients undergoing cardiac surgery. Patients in the supplement 
      group (n = 7) took a supplement enriched in omega-3 fatty acids (Impact((R))) in 
      addition to a hospital diet for five successive days before surgery; those in the 
      control group (n = 7) took only hospital diet and did not take Impact((R)). Blood 
      samples in both groups were collected at same time points. Before surgery, 
      samples were collected five days before surgery, at the start of supplementation 
      (baseline), and the end of supplementation (postoperative day (POD)-0). After 
      surgery, samples were collected on POD-1 and POD-7. The expression of human 
      leukocyte antigen (HLA)-DR, the ratio of CD4-/CD8-positive cells, the production 
      of interferon (IFN)-gamma by CD4-positive cells, plasma levels of cytokines, and 
      leukocyte-platelet aggregates were measured. Before surgery (POD-0), the 
      supplement caused significant increases in HLA-DR expression, CD4/CD8 ratio, and 
      plasma levels of IFN-gamma; these levels were significantly higher compared to those 
      in the control group (P < 0.05, respectively). After surgery (POD-1), all values 
      dramatically decreased in comparison with those of POD-0; however, the values in 
      the supplement group were significantly higher compared to their respective 
      markers in the control group (P < 0.05, respectively). Significant differences of 
      HLA-DR expression and CD4/CD8 ratio persisted through POD-7. Before surgery 
      (POD-0), plasma levels of interleukin (IL)-10 in the supplement group decreased 
      significantly compared with those in the control group (P < 0.05). After surgery 
      (POD-1), plasma levels of IL-10 in both the control and supplement groups 
      increased; these levels in the supplement group were significantly lower than 
      those in the control group (P < 0.05). Significant decreases in the percentage of 
      leukocyte-platelet aggregates were found after supplementation; the difference 
      between the supplement and the control groups was found on POD-0 and POD-1 (P < 
      0.05, respectively). In conclusion, the dietary supplement increased HLA-DR 
      expression, the CD4/CD8 ratio, and the production of IFN-gamma by CD4-positive cells; 
      conversely, the levels of IL-10 and the formation of leukocyte-platelet 
      aggregates before and after surgery were suppressed. These beneficial effects may 
      decrease the incidence of complications after surgery.
FAU - Iwase, Harunobu
AU  - Iwase H
AD  - Department of Biopharmaceutics, Nihon Pharmaceutical University, Saitama, Japan.
FAU - Kariyazono, Hiroko
AU  - Kariyazono H
AD  - Division of Pharmaceutical Health Care and Sciences, Department of Pharmacy, 
      Nagasaki International University, Nagasaki, Japan.
FAU - Arima, Junko
AU  - Arima J
AD  - Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and 
      Dental Sciences, Kagoshima University, Japan.
FAU - Yamamoto, Hiroyuki
AU  - Yamamoto H
AD  - Department of Thoracic, Cardiovascular and Hepatobiliary-pancreatic Surgery, 
      Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 
      Japan.
FAU - Nakamura, Kazuo
AU  - Nakamura K
AD  - Department of Biopharmaceutics, Nihon Pharmaceutical University, Saitama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140525
PL  - United States
TA  - Nutr Metab Insights
JT  - Nutrition and metabolic insights
JID - 101550186
PMC - PMC4051814
OTO - NOTNLM
OT  - CD4/CD8 ratio
OT  - HLA-DR
OT  - dietary supplement
OT  - interferon-gamma
OT  - platelet-leukocyte aggregates
EDAT- 2014/06/17 06:00
MHDA- 2014/06/17 06:01
PMCR- 2014/05/25
CRDT- 2014/06/17 06:00
PHST- 2013/12/05 00:00 [received]
PHST- 2014/02/03 00:00 [revised]
PHST- 2014/02/03 00:00 [accepted]
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2014/06/17 06:01 [medline]
PHST- 2014/05/25 00:00 [pmc-release]
AID - nmi-7-2014-039 [pii]
AID - 10.4137/NMI.S13810 [doi]
PST - epublish
SO  - Nutr Metab Insights. 2014 May 25;7:39-46. doi: 10.4137/NMI.S13810. eCollection 
      2014.