PMID- 24932270
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240321
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 7
IP  - 6
DP  - 2014 Jun
TI  - An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine 
      without neurofibromatosis: Case report and review of the literature.
PG  - 1965-1969
AB  - A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant 
      tumor that develops or differentiates from cells in the peripheral nerve sheath. 
      This tumor is commonly associated with neurofibromatosis type 1 (NF1) and 
      previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare 
      and a case of the lumbar spine in a patient without NF1 is reported in the 
      present study, with a review of the intraosseous MPNST literature. A 45-year-old 
      female presented with a 1-month history of severe lower back pain and pain 
      radiating to the left leg. A total en bloc spondylectomy of L4 was performed. The 
      postoperative histopathological diagnosis was MPNST with deletion of NF1, 
      confirmed by dual-color fluorescence in situ hybridization (FISH) analysis. The 
      tumor recurred 1 month following the surgery. Although adjuvant chemotherapy was 
      administered, the patient succumbed due to intramedullary dissemination and 
      carcinomatous meningitis 8 months following the initial consultation. NF1 
      deletion by FISH analysis may be particularly useful in distinguishing MPNST from 
      other high-grade malignancies with overlapping morphological features.
FAU - Suzuki, Kayo
AU  - Suzuki K
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama City, Toyoma 939-0194, Japan.
FAU - Yasuda, Taketoshi
AU  - Yasuda T
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama City, Toyoma 939-0194, Japan.
FAU - Hori, Takeshi
AU  - Hori T
AD  - Department of Orthopaedic Surgery, Iiyama Red Cross Hospital, Iiyama City, Nagano 
      389-2295, Japan.
FAU - Watanabe, Kenta
AU  - Watanabe K
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama City, Toyoma 939-0194, Japan.
FAU - Kanamori, Masahiko
AU  - Kanamori M
AD  - First Department of Human Science, Faculty of Medicine, University of Toyama, 
      Toyama City, Toyoma 939-0194, Japan.
FAU - Kimura, Tomoatsu
AU  - Kimura T
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama City, Toyoma 939-0194, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140321
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4049692
OTO - NOTNLM
OT  - intraosseous malignant peripheral nerve sheath tumor
OT  - spine
OT  - total en bloc spondylectomy
EDAT- 2014/06/17 06:00
MHDA- 2014/06/17 06:01
PMCR- 2014/03/21
CRDT- 2014/06/17 06:00
PHST- 2013/09/11 00:00 [received]
PHST- 2014/03/04 00:00 [accepted]
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2014/06/17 06:01 [medline]
PHST- 2014/03/21 00:00 [pmc-release]
AID - ol-07-06-1965 [pii]
AID - 10.3892/ol.2014.1987 [doi]
PST - ppublish
SO  - Oncol Lett. 2014 Jun;7(6):1965-1969. doi: 10.3892/ol.2014.1987. Epub 2014 Mar 21.