PMID- 24932613
OWN - NLM
STAT- MEDLINE
DCOM- 20150601
LR  - 20221207
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 28
IP  - 13
DP  - 2014 Aug 24
TI  - Mitochondrial DNA variation and virologic and immunological HIV outcomes in 
      African Americans.
PG  - 1871-8
LID - 10.1097/QAD.0000000000000371 [doi]
AB  - OBJECTIVE: To evaluate the impact of mitochondrial DNA (mtDNA) haplogroups on 
      virologic and immunological outcomes of HIV infection. DESIGN: HAART-naive 
      African American adolescent participants to the Reaching for Excellence in 
      Adolescent Care and Health study. METHODS: The mtDNA haplogroups were inferred 
      from sequenced mtDNA hypervariable regions HV1 and HV2 and their predictive value 
      on HIV outcomes were evaluated in linear mixed models, controlled for human 
      leukocyte antigen (HLA)-B27, HLA-B57 and HLA-B35-Px alleles and other covariates. 
      RESULTS: We report data showing that the mtDNA L2 lineage, a group composed of 
      L2a, L2b and L2e mtDNA haplogroups in the studied population, is significantly 
      associated (beta  = -0.08; Bonferroni-adjusted P = 0.004) with decline of CD4 T 
      cells (median loss of 8 +/- 1 cells per month) in HAART-naive HIV-infected 
      individuals of African American descent (n = 133). No significant association (P 
      < 0.05) with set-point viral load was observed with any of the tested mtDNA 
      haplogroups. The present data concur with previous findings in the AIDS Clinical 
      Trials Group study 384, implicating the L2 lineage with slower CD4 T-cell 
      recovery after antiretroviral therapy in African Americans. CONCLUSIONS: Whereas 
      the L2 lineage showed an association with unfavorable immunological outcomes of 
      HIV infection, its phylogenetic divergence from J and U5a, two lineages 
      associated with accelerated HIV progression in European Americans, raises the 
      possibility that interactions with common nucleus-encoded variants drive HIV 
      progression. Disentangling the effects of mitochondrial and nuclear gene variants 
      on the outcomes of HIV infection is an important step to be taken toward a better 
      understanding of HIV/AIDS pathogenesis and pharmacogenomics.
FAU - Aissani, Brahim
AU  - Aissani B
AD  - aDepartment of Epidemiology bDepartment of Medicine, University of Alabama at 
      Birmingham, Birmingham, Alabama, USA.
FAU - Shrestha, Sadeep
AU  - Shrestha S
FAU - Wiener, Howard W
AU  - Wiener HW
FAU - Tang, Jianming
AU  - Tang J
FAU - Kaslow, Richard A
AU  - Kaslow RA
FAU - Wilson, Craig M
AU  - Wilson CM
LA  - eng
GR  - U01 HD032842/HD/NICHD NIH HHS/United States
GR  - U01 HD040533/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Adolescent
MH  - Black or African American
MH  - Child
MH  - Cohort Studies
MH  - DNA, Mitochondrial/chemistry/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Variation
MH  - HIV Infections/*immunology/*virology
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Sequence Analysis, DNA
MH  - Treatment Outcome
PMC - PMC5004594
MID - NIHMS811646
EDAT- 2014/06/17 06:00
MHDA- 2015/06/02 06:00
PMCR- 2016/08/30
CRDT- 2014/06/17 06:00
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2015/06/02 06:00 [medline]
PHST- 2016/08/30 00:00 [pmc-release]
AID - 10.1097/QAD.0000000000000371 [doi]
PST - ppublish
SO  - AIDS. 2014 Aug 24;28(13):1871-8. doi: 10.1097/QAD.0000000000000371.