PMID- 24932776
OWN - NLM
STAT- MEDLINE
DCOM- 20150513
LR  - 20140922
IS  - 1873-6971 (Electronic)
IS  - 0367-326X (Linking)
VI  - 98
DP  - 2014 Oct
TI  - Emodin opposes chronic unpredictable mild stress induced depressive-like behavior 
      in mice by upregulating the levels of hippocampal glucocorticoid receptor and 
      brain-derived neurotrophic factor.
PG  - 1-10
LID - S0367-326X(14)00160-9 [pii]
LID - 10.1016/j.fitote.2014.06.007 [doi]
AB  - Emodin, the major active component of Rhubarb, has shown neuroprotective 
      activity. This study is attempted to investigate whether emodin possesses 
      beneficial effects on chronic unpredictable mild stress (CUMS)-induced behavioral 
      deficits (depression-like behaviors) and explore the possible mechanisms. ICR 
      mice were subjected to chronic unpredictable mild stress for 42 consecutive days. 
      Then, emodin and fluoxetine (positive control drug) were administered for 21 
      consecutive days at the last three weeks of CUMS procedure. The classical 
      behavioral tests: open field test (OFT), sucrose preference test (SPT), tail 
      suspension test (TST) and forced swimming test (FST) were applied to evaluate the 
      antidepressant effects of emodin. Then plasma corticosterone concentration, 
      hippocampal glucocorticoid receptor (GR) and brain-derived neurotrophic factor 
      (BDNF) levels were tested to probe the mechanisms. Our results indicated that 6 
      weeks of CUMS exposure induced significant depression-like behavior, with high, 
      plasma corticosterone concentration and low hippocampal GR and BDNF expression 
      levels. Whereas, chronic emodin (20, 40 and 80 mg/kg) treatments reversed the 
      behavioral deficiency induced by CUMS exposure. Treatment with emodin normalized 
      the change of plasma corticosterone level, which demonstrated that emodin could 
      partially restore CUMS-induced HPA axis impairments. Besides, hippocampal GR 
      (mRNA and protein) and BDNF (mRNA) expressions were also up-regulated after 
      emodin treatments. In conclusion, emodin remarkably improved depression-like 
      behavior in CUMS mice and its antidepressant activity is mediated, at least in 
      part, by the up-regulating GR and BDNF levels in hippocampus.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Li, Meng
AU  - Li M
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Fu, Qiang
AU  - Fu Q
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Li, Shanshan
AU  - Li S
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Xue, Jinsong
AU  - Xue J
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Ma, Shiping
AU  - Ma S
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China. Electronic address: spma@cpu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140614
PL  - Netherlands
TA  - Fitoterapia
JT  - Fitoterapia
JID - 16930290R
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Glucocorticoid)
RN  - KA46RNI6HN (Emodin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - Depression/drug therapy
MH  - Disease Models, Animal
MH  - Emodin/*pharmacology
MH  - Hippocampus/*drug effects
MH  - Male
MH  - Mice, Inbred ICR
MH  - Receptors, Glucocorticoid/*metabolism
MH  - Stress, Psychological/*drug therapy
MH  - Up-Regulation
OTO - NOTNLM
OT  - Antidepressant
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Chronic unpredictable mild stress (CUMS)
OT  - Emodin
OT  - Glucocorticoid receptor (GR)
EDAT- 2014/06/17 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/06/17 06:00
PHST- 2014/03/21 00:00 [received]
PHST- 2014/06/05 00:00 [revised]
PHST- 2014/06/06 00:00 [accepted]
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - S0367-326X(14)00160-9 [pii]
AID - 10.1016/j.fitote.2014.06.007 [doi]
PST - ppublish
SO  - Fitoterapia. 2014 Oct;98:1-10. doi: 10.1016/j.fitote.2014.06.007. Epub 2014 Jun 
      14.