PMID- 24932803
OWN - NLM
STAT- MEDLINE
DCOM- 20141008
LR  - 20181202
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 48
IP  - 14
DP  - 2014 Jul 15
TI  - In vivo tracing uptake and elimination of organic pesticides in fish muscle.
PG  - 8012-20
LID - 10.1021/es5009032 [doi]
AB  - Bioconcentration factors (BCFs) measured in the laboratory are important for 
      characterizing the bioaccumulative properties of chemicals entering the 
      environment, especially the potential persistent organic pollutants (POPs), which 
      can pose serious adverse effects on ecosystem and human health. Traditional 
      lethal analysis methods are time-consuming and sacrifice too many experimental 
      animals. In the present study, in vivo solid-phase microextraction (SPME) was 
      introduced to trace the uptake and elimination processes of pesticides in living 
      fish. BCFs and elimination kinetic coefficients of the pesticides were recorded 
      therein. Moreover, the metabolism of fenthion was also traced with in vivo SPME. 
      The method was time-efficient and laborsaving. Much fewer experimental animals 
      were sacrificed during the tracing. In general, this study opened up an 
      opportunity to measure BCFs cheaply in laboratories for the registering of 
      emerging POPs and inspecting of suspected POPs, as well as demonstrated the 
      potential application of in vivo SPME in the study of toxicokinetics of 
      pollutants.
FAU - Xu, Jianqiao
AU  - Xu J
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University , 
      Guangzhou, 510275 Guangdong, China.
FAU - Luo, Junpeng
AU  - Luo J
FAU - Ruan, Jingwen
AU  - Ruan J
FAU - Zhu, Fang
AU  - Zhu F
FAU - Luan, Tiangang
AU  - Luan T
FAU - Liu, Hong
AU  - Liu H
FAU - Jiang, Ruifen
AU  - Jiang R
FAU - Ouyang, Gangfeng
AU  - Ouyang G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140620
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Organic Chemicals)
RN  - 0 (Pesticides)
RN  - BL0L45OVKT (Fenthion)
SB  - IM
MH  - Animals
MH  - *Environmental Monitoring
MH  - Fenthion/metabolism
MH  - Humans
MH  - Hydrocarbons, Chlorinated/metabolism
MH  - Muscles/*metabolism
MH  - Organic Chemicals/*metabolism
MH  - Pesticides/*metabolism
MH  - Solid Phase Microextraction
MH  - Tilapia/*metabolism
EDAT- 2014/06/17 06:00
MHDA- 2014/10/09 06:00
CRDT- 2014/06/17 06:00
PHST- 2014/06/17 06:00 [entrez]
PHST- 2014/06/17 06:00 [pubmed]
PHST- 2014/10/09 06:00 [medline]
AID - 10.1021/es5009032 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2014 Jul 15;48(14):8012-20. doi: 10.1021/es5009032. Epub 
      2014 Jun 20.