PMID- 24934802
OWN - NLM
STAT- MEDLINE
DCOM- 20150205
LR  - 20140619
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 52
IP  - 5
DP  - 2014 Jul
TI  - Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties.
PG  - 546-51
LID - 10.1093/mmy/myu024 [doi]
AB  - Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by 
      the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in 
      some countries of Latin America and can cause a high-burden fungal infection with 
      significant morbidity and mortality. The peptide P10, which demonstrates immune 
      protection against experimental PCM, was radiolabeled with a radioisotope and 
      evaluated in vivo. The radiolabeling was conducted to trace the pharmacokinetics 
      of the molecule in principal organs and tissues. This was achieved with high 
      radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood 
      clearance that was mainly renal; however, hepatobiliar excretion was also, with 
      marked uptake in cervical lymph nodes. This profile may be useful for the 
      development of a prophylactic drug or vaccine for patients exposed to PCM.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Faintuch, Bluma L
AU  - Faintuch BL
AD  - Radiopharmacy, Institute of Energy and Nuclear Research, Sao Paulo 
      faintuch@ipen.br blfaintuch@hotmail.com.
FAU - Oliveira, Erica A
AU  - Oliveira EA
AD  - Radiopharmacy, Institute of Energy and Nuclear Research, Sao Paulo.
FAU - Munoz, Julian E
AU  - Munoz JE
AD  - Institute of Biomedical Sciences, Department of Microbiology, University of Sao 
      Paulo.
FAU - Travassos, Luiz R
AU  - Travassos LR
AD  - Department of Microbiology, Immunology and Parasitology, Federal University of 
      Sao Paulo.
FAU - Taborda, Carlos P
AU  - Taborda CP
AD  - Institute of Biomedical Sciences, Department of Microbiology, University of Sao 
      Paulo Laboratory of Medical Mycology, Instituto de Medicina Tropical Sao Paulo, 
      IMTSP Laboratorio de Investigacao Medica 53/LIM 53, University of Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140615
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (Antifungal Agents)
RN  - 0 (Chelating Agents)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/*pharmacokinetics
MH  - Chelating Agents/chemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Paracoccidioides/*immunology
MH  - Paracoccidioidomycosis/*microbiology/prevention & control
MH  - Peptides/*pharmacokinetics
OTO - NOTNLM
OT  - P. brasiliensis
OT  - P10 peptide
OT  - biodistribution evaluation
OT  - radiolabeling
EDAT- 2014/06/18 06:00
MHDA- 2015/02/06 06:00
CRDT- 2014/06/18 06:00
PHST- 2014/06/18 06:00 [entrez]
PHST- 2014/06/18 06:00 [pubmed]
PHST- 2015/02/06 06:00 [medline]
AID - myu024 [pii]
AID - 10.1093/mmy/myu024 [doi]
PST - ppublish
SO  - Med Mycol. 2014 Jul;52(5):546-51. doi: 10.1093/mmy/myu024. Epub 2014 Jun 15.