PMID- 24934904
OWN - NLM
STAT- MEDLINE
DCOM- 20150226
LR  - 20160526
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 157
IP  - 1-3
DP  - 2014 Aug
TI  - The relationship between serum brain-derived neurotrophic factor (BDNF) and 
      cardiometabolic indices in schizophrenia.
PG  - 244-8
LID - S0920-9964(14)00258-8 [pii]
LID - 10.1016/j.schres.2014.05.024 [doi]
AB  - Brain derived neurotrophic factor (BDNF), which has been implicated in the 
      pathogenesis of schizophrenia, has been recently shown to be involved in the 
      regulation of metabolism and energy homeostasis. This study seeks to examine the 
      relationship between BDNF, metabolic indices and cardiovascular (CVD) risk in 
      patients with schizophrenia. Medical histories, demographic information and 
      anthropometric measurements were collected and analyzed from 61 participants with 
      schizophrenia. Fasting glucose and lipids were measured in a central laboratory, 
      and serum BDNF was analyzed using commercially available enzyme-linked 
      immunosorbent assay (ELISA). The 10-year CVD risk for each participant was 
      computed using the Framingham risk score (FRS). Linear regressions were performed 
      to examine the relationships between serum BDNF with body mass index (BMI), blood 
      pressure (BP), triglycerides (TG), total cholesterol, high-density lipoprotein 
      cholesterol (HDL-C) and glucose. To examine the relationship between serum BDNF 
      and FRS, serum BDNF was categorized into quartiles, and a multiple regression was 
      performed. After adjusting for age, gender and current smoking status, diastolic 
      BP (dBP) (p=0.045) and TG (p=0.015) were found to be significantly associated 
      with serum BDNF. Participants in the highest quartile of serum BDNF had a 3.3 
      times increase in FRS over those in the lowest quartile. Our findings support the 
      possible regulatory role of BDNF in metabolism and cardiovascular homeostasis 
      among patients with schizophrenia similar to that observed among the non-mentally 
      ill. Serum BDNF not only present itself as a candidate biomarker of schizophrenia 
      but also might be a viable marker of metabolic co-morbidities associated with 
      schizophrenia.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Nurjono, Milawaty
AU  - Nurjono M
AD  - Research Division, Institute of Mental Health, Singapore, Singapore.
FAU - Tay, Yi Hang
AU  - Tay YH
AD  - Ministry of Health Holdings, Singapore, Singapore.
FAU - Lee, Jimmy
AU  - Lee J
AD  - Research Division, Institute of Mental Health, Singapore, Singapore; Department 
      of General Psychiatry 1, Institute of Mental Health, Singapore, Singapore; 
      Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address: 
      jimmy_lee@imh.com.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140614
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cardiovascular Diseases/epidemiology/*physiopathology
MH  - China
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Schizophrenia/epidemiology/*physiopathology
MH  - Triglycerides/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - Framingham risk score
OT  - Metabolic indices
EDAT- 2014/06/18 06:00
MHDA- 2015/02/27 06:00
CRDT- 2014/06/18 06:00
PHST- 2014/03/03 00:00 [received]
PHST- 2014/04/25 00:00 [revised]
PHST- 2014/05/17 00:00 [accepted]
PHST- 2014/06/18 06:00 [entrez]
PHST- 2014/06/18 06:00 [pubmed]
PHST- 2015/02/27 06:00 [medline]
AID - S0920-9964(14)00258-8 [pii]
AID - 10.1016/j.schres.2014.05.024 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Aug;157(1-3):244-8. doi: 10.1016/j.schres.2014.05.024. Epub 
      2014 Jun 14.