PMID- 24934908 OWN - NLM STAT- MEDLINE DCOM- 20140810 LR - 20211021 IS - 1534-6315 (Electronic) IS - 1529-7322 (Linking) VI - 14 IP - 7 DP - 2014 Jul TI - Venom immunotherapy: an updated review. PG - 449 LID - 10.1007/s11882-014-0449-1 [doi] AB - Venom immunotherapy (VIT) is the most effective form of specific immunotherapy to date. Hitherto, several relevant queries remain unanswered, namely optimal doses, duration, and means of assessment. Important progress has been lately made in terms of diagnosis by means of component-resolved diagnosis. Moreover, basophil activation test results in patients with negative serum immunoglobulin E (IgE) and skin prick test confer this technique a promising future, although these outcomes shall be considered with caution. This review aims to unravel the important advances made on diagnosis, management, and prognosis and also focuses on several undetermined aspects of VIT. FAU - Antolin-Amerigo, Dario AU - Antolin-Amerigo D AD - Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Principe de Asturias, Departamento de Medicina, Universidad de Alcala, Carretera Alcala-Meco S/N, 28805, Alcala de Henares, Madrid, Spain, dario.antolin@gmail.com. FAU - Moreno Aguilar, Carmen AU - Moreno Aguilar C FAU - Vega, Arantza AU - Vega A FAU - Alvarez-Mon, Melchor AU - Alvarez-Mon M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Curr Allergy Asthma Rep JT - Current allergy and asthma reports JID - 101096440 RN - 0 (Arthropod Venoms) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Anaphylaxis/diagnosis/etiology MH - Arthropod Venoms/adverse effects/*therapeutic use MH - Humans MH - Immunoglobulin E/blood MH - *Immunotherapy/adverse effects MH - Insect Bites and Stings/complications/diagnosis/immunology/*therapy MH - Mastocytosis/etiology MH - Practice Guidelines as Topic MH - Risk Factors MH - Skin Tests EDAT- 2014/06/18 06:00 MHDA- 2014/08/12 06:00 CRDT- 2014/06/18 06:00 PHST- 2014/06/18 06:00 [entrez] PHST- 2014/06/18 06:00 [pubmed] PHST- 2014/08/12 06:00 [medline] AID - 10.1007/s11882-014-0449-1 [doi] PST - ppublish SO - Curr Allergy Asthma Rep. 2014 Jul;14(7):449. doi: 10.1007/s11882-014-0449-1.