PMID- 24935068
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20220330
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 20
DP  - 2014 Jun 17
TI  - Efficacy and safety of flurbiprofen axetil in the prevention of pain on propofol 
      injection: a systematic review and meta-analysis.
PG  - 995-1002
LID - 10.12659/MSM.890102 [doi]
AB  - BACKGROUND: Pain on injection is an acknowledged adverse effect (AE) of propofol 
      administration for the induction of general anesthesia. Flurbiprofen axetil has 
      been reported to reduce the pain of injection. However, results of published 
      papers on the efficacy of flurbiprofen axetil in managing pain on injection of 
      propofol are inconsistent. MATERIAL/METHODS: We conducted a comprehensive 
      meta-analysis of studies to appraise the efficacy and safety of flurbiprofen 
      axetil for controlling pain induced by propofol injection. The pooled risk ratio 
      (RR) with corresponding 95% confidence intervals (CI) was calculated employing 
      fixed- or random-effects models, depending upon the heterogeneity of the included 
      trials. RESULTS: Compared with the placebo group, flurbiprofen axetil allows more 
      patients to have no pain (RR 3.51, 95% CI 2.22-5.55, p=0.000), and decreases the 
      cumulative number of patients with mild, moderate, and severe pain on injecting 
      propofol (RR 0.70, 95% CI 0.58-0.86, p=0.000; RR 0.59, 95% CI 0.46-0.75, p=0.000; 
      RR 0.25, 95% CI 0.16-0.38, p=0.000, respectively). In the stratified analysis by 
      the doses, flurbiprofen axetil at a dose of over 50 mg was found to be effective 
      in reducing propofol-induced pain on injection; however, there were no 
      significant differences in relieving pain between treatment and placebo groups 
      with flurbiprofen axetil at a dose of 25 mg. In terms of drug safety, there were 
      no adverse effects (AEs) reported between flurbiprofen axetil-based regimens and 
      placebo regimens. CONCLUSIONS: Flurbiprofen axetil, an injectable prodrug of 
      flurbiprofen, can significantly prevent or relieve the pain induced by propofol 
      injection. More studies are required to assess its adverse effects.
FAU - Zhang, Lieliang
AU  - Zhang L
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Zhu, Juan
AU  - Zhu J
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Xu, Lei
AU  - Xu L
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Zhang, Xunlei
AU  - Zhang X
AD  - Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Wang, Hongyu
AU  - Wang H
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Luo, Zhonghua
AU  - Luo Z
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Zhao, Yamei
AU  - Zhao Y
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Yu, Yi
AU  - Yu Y
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Shi, Hongwei
AU  - Shi H
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
FAU - Bao, Hongguang
AU  - Bao H
AD  - Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China (mainland).
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140617
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 5GRO578KLP (Flurbiprofen)
RN  - I0OU31PUI5 (flurbiprofen axetil)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Flurbiprofen/adverse effects/*analogs & derivatives/therapeutic use
MH  - Humans
MH  - Pain/*drug therapy/etiology/*prevention & control
MH  - Propofol/*administration & dosage/*adverse effects
MH  - Publication Bias
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC4070992
EDAT- 2014/06/18 06:00
MHDA- 2014/12/19 06:00
PMCR- 2014/06/17
CRDT- 2014/06/18 06:00
PHST- 2014/06/18 06:00 [entrez]
PHST- 2014/06/18 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
PHST- 2014/06/17 00:00 [pmc-release]
AID - 890102 [pii]
AID - 10.12659/MSM.890102 [doi]
PST - epublish
SO  - Med Sci Monit. 2014 Jun 17;20:995-1002. doi: 10.12659/MSM.890102.