PMID- 24936185
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140617
LR  - 20211021
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 6
DP  - 2014
TI  - Delayed plastic responses to anodal tDCS in older adults.
PG  - 115
LID - 10.3389/fnagi.2014.00115 [doi]
LID - 115
AB  - Despite the abundance of research reporting the neurophysiological and behavioral 
      effects of transcranial direct current stimulation (tDCS) in healthy young adults 
      and clinical populations, the extent of potential neuroplastic changes induced by 
      tDCS in healthy older adults is not well understood. The present study compared 
      the extent and time course of anodal tDCS-induced plastic changes in primary 
      motor cortex (M1) in young and older adults. Furthermore, as it has been 
      suggested that neuroplasticity and associated learning depends on the 
      brain-derived neurotrophic factor (BDNF) gene polymorphisms, we also assessed the 
      impact of BDNF polymorphism on these effects. Corticospinal excitability was 
      examined using transcranial magnetic stimulation before and following (0, 10, 20, 
      30 min) anodal tDCS (30 min, 1 mA) or sham in young and older adults. While the 
      overall extent of increases in corticospinal excitability induced by anodal tDCS 
      did not vary reliably between young and older adults, older adults exhibited a 
      delayed response; the largest increase in corticospinal excitability occurred 30 
      min following stimulation for older adults, but immediately post-stimulation for 
      the young group. BDNF genotype did not result in significant differences in the 
      observed excitability increases for either age group. The present study suggests 
      that tDCS-induced plastic changes are delayed as a result of healthy aging, but 
      that the overall efficacy of the plasticity mechanism remains unaffected.
FAU - Fujiyama, Hakuei
AU  - Fujiyama H
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania 
      Hobart, TAS, Australia ; Movement Control and Neuroplasticity Research Group, 
      Department of Kinesiology KU Leuven, Leuven, Belgium.
FAU - Hyde, Jane
AU  - Hyde J
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania 
      Hobart, TAS, Australia.
FAU - Hinder, Mark R
AU  - Hinder MR
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania 
      Hobart, TAS, Australia.
FAU - Kim, Seok-Jin
AU  - Kim SJ
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania 
      Hobart, TAS, Australia ; Motor Behavior Laboratory, Department of Physical 
      Education, Seoul National University Seoul, South Korea.
FAU - McCormack, Graeme H
AU  - McCormack GH
AD  - Wicking Dementia Research and Education Centre, University of Tasmania Hobart, 
      TAS, Australia.
FAU - Vickers, James C
AU  - Vickers JC
AD  - Wicking Dementia Research and Education Centre, University of Tasmania Hobart, 
      TAS, Australia.
FAU - Summers, Jeffery J
AU  - Summers JJ
AD  - Human Motor Control Laboratory, School of Medicine, University of Tasmania 
      Hobart, TAS, Australia ; Research Institute for Sport and Exercise Sciences, 
      Liverpool John Moores University Liverpool, UK.
LA  - eng
PT  - Journal Article
DEP - 20140606
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4047559
OTO - NOTNLM
OT  - aging
OT  - brain-derived neurotrophic factor
OT  - plasticity
OT  - transcranial direct current stimulation
OT  - transcranial magnetic stimulation
EDAT- 2014/06/18 06:00
MHDA- 2014/06/18 06:01
PMCR- 2014/01/01
CRDT- 2014/06/18 06:00
PHST- 2014/04/14 00:00 [received]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/06/18 06:00 [entrez]
PHST- 2014/06/18 06:00 [pubmed]
PHST- 2014/06/18 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2014.00115 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2014 Jun 6;6:115. doi: 10.3389/fnagi.2014.00115. 
      eCollection 2014.