PMID- 24936562
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 20
IP  - 11
DP  - 2014 Nov
TI  - Serum monocyte chemokine protein-1 levels before and after parathyroidectomy in 
      patients with primary hyperparathyroidism.
PG  - 1165-9
LID - 10.4158/EP14104.OR [doi]
AB  - OBJECTIVE: To investigate the effects of parathyroidectomy on serum monocyte 
      chemokine protein-1 (MCP-1) levels in patients with primary hyperparathyroidism 
      (PHPT). METHODS: Forty-three PHPT patients, age 56 +/- 12 years, underwent 
      minimally invasive parathyroidectomy. Serum samples were collected at 0 and 15 to 
      20 minutes after parathyroid adenoma removal. Serum samples were stored at -70 degrees C 
      until time of assay. RESULTS: In 40 PHPT patients with a single adenoma, MCP-1 
      levels decreased from 342 +/- 103 to 250 +/- 77 pg/mL (P<.001) 15 to 20 minutes after 
      parathyroid adenoma removal. MCP-1 levels were positively correlated with intact 
      parathyroid hormone (PTH) levels (R = 0.47; P<.01). In 3 PHPT patients with 
      double parathyroid adenoma, MCP-1 levels did not decrease after removal of the 
      first adenoma but decreased 15 to 20 minutes after second adenoma removal. 
      CONCLUSION: Our results provide evidence that the decrease in serum intact PTH 
      due to minimally invasive parathyroidectomy results in an immediate decrease in 
      serum MCP-1 levels.
FAU - Patel, Hemal
AU  - Patel H
AD  - Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
FAU - Trooskin, Stanley
AU  - Trooskin S
AD  - Division of General Surgery, Departments of Medicine and Surgery, Rutgers Robert 
      Wood Johnson Medical School.
FAU - Shapses, Sue
AU  - Shapses S
AD  - Department of Nutritional Sciences, Rutgers University, New Brunswick, New 
      Jersey.
FAU - Sun, Wei
AU  - Sun W
AD  - Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
FAU - Wang, Xiangbing
AU  - Wang X
AD  - Division of Endocrinology, Rutgers Robert Wood Johnson Medical School.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
SB  - IM
EDAT- 2014/06/18 06:00
MHDA- 2014/06/18 06:01
CRDT- 2014/06/18 06:00
PHST- 2014/06/18 06:00 [entrez]
PHST- 2014/06/18 06:00 [pubmed]
PHST- 2014/06/18 06:01 [medline]
AID - S1530-891X(20)41923-8 [pii]
AID - 10.4158/EP14104.OR [doi]
PST - ppublish
SO  - Endocr Pract. 2014 Nov;20(11):1165-9. doi: 10.4158/EP14104.OR.