PMID- 24937394
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20151119
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 28
IP  - 2
DP  - 2013 Dec 20
TI  - Coffee consumption attenuates insulin resistance and glucose intolerance in rats 
      fed on high-sucrose diet.
PG  - 179-85
AB  - Several epidemiological evidences indicate that consumption of coffee is 
      associated with a lower risk of type 2 diabetes mellitus (T2DM) however; there is 
      dearth of experimental data to support these observations. Given that 
      associations do not necessarily infer causality, the present study was designed 
      to investigate the effect of coffee consumption on glucose regulation, T2DM and 
      the probable mechanisms of action, using an animal model. The effect of coffee 
      (2-fold dilution) by oral gavage on normal and high sucrose-solution (HSS) fed 
      (30 % w/v) rats was evaluated. The results showed that consumption of coffee 
      significantly increase glucose tolerance and insulin sensitivity (p<0.05) 
      along with significant improvement in SOD and GSH activities. In addition, lipid 
      indices such as TG and LDL as well as the lipid peroxidation marker (MDA) were 
      markedly reduced (p<0.05) in rats fed with coffee compared with that of the 
      HSS fed rats. These findings suggest that coffee consumption improves insulin 
      sensitivity, glucose tolerance in HSS-fed rat possibly via inhibition of 
      oxidative stress.
FAU - Morakinyo, A O
AU  - Morakinyo AO
AD  - Department of Physiology, College of Medicine of the University of Lagos, Lagos. 
      morakinyofemi@yahoo.com.
FAU - Adekunbi, D A
AU  - Adekunbi DA
FAU - Dada, K A
AU  - Dada KA
FAU - Adegoke, O A
AU  - Adegoke OA
LA  - eng
PT  - Journal Article
DEP - 20131220
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the 
      Physiological Society of Nigeria
JID - 8811109
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Coffee)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - *Coffee
MH  - *Dietary Sucrose
MH  - Disease Models, Animal
MH  - Glucose Intolerance/blood/chemically induced/*prevention & control
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Lipid Peroxidation
MH  - Lipids/blood
MH  - Male
MH  - Oxidative Stress
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2013/01/01 00:00
MHDA- 2015/02/20 06:00
CRDT- 2014/06/18 06:00
PHST- 2014/04/11 00:00 [received]
PHST- 2014/04/11 00:00 [accepted]
PHST- 2014/06/18 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
PST - epublish
SO  - Niger J Physiol Sci. 2013 Dec 20;28(2):179-85.